Registration Dossier
Registration Dossier
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EC number: 938-980-5 | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Principles of method if other than guideline:
- Because of the chemical nature of the test item and the impossibility to conduct a classic shake flask test to determine experimentally the partition coefficient (n-octanol/water), an estimation of this parameter was calculated on the basis of the test item solubility in the two pure solvents.
- GLP compliance:
- no
- Type of method:
- other: on the basis of the test item solubility
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Glycine max. (L.) Merr. (Fabacee) aqueous alcoholic ext., concentrate by sequential extractions and filtration
- EC Number:
- 938-980-5
- IUPAC Name:
- Glycine max. (L.) Merr. (Fabacee) aqueous alcoholic ext., concentrate by sequential extractions and filtration
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Test item identification : Soybean (Glycine max) dry purified extract
Active ingredient content : 100 % w/w (from the Test Substance Data Sheet (TSDS)
Batch number : 30432/M1
Constituent 1
Results and discussion
Partition coefficientopen allclose all
- Type:
- log Pow
- Partition coefficient:
- ca. 0
- Temp.:
- 22 °C
- Remarks on result:
- other: no data about pH
- Type:
- Pow
- Partition coefficient:
- ca. 1
- Temp.:
- 22 °C
- Remarks on result:
- other: no data about pH
- Details on results:
- About 0.10 g of the test item remained undissolved adding a total of 1000 mL of n-octanol at room temperature (ca. 22°C).
Therefore the test item solubility in n-octanol was estimated to be lower than 0.1 g/L.
Since also the water solubility value from the Technical Report CH – 204/2013 resulted to be < 0.1 g/L, a similar affinity of the test item for both solvent can be estimated.
Taking into consideration the ratio between the two solubility values, the test item partition coefficient can be estimated to be near 1 and therefore the log Pow near 0.
Applicant's summary and conclusion
- Conclusions:
- From the obtained experimental data, it can be concluded that the Partition Coefficient (Pow) of Soybean (Glycine max) dry purified extract sample at room temperature (ca. 22°C) is estimated to be near 1 and therefore the log Pow near 0.
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