Registration Dossier
Registration Dossier
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EC number: 214-715-2 | CAS number: 1189-71-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1976
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Chlorosulphonyl isocyanate
- EC Number:
- 214-715-2
- EC Name:
- Chlorosulphonyl isocyanate
- Cas Number:
- 1189-71-5
- Molecular formula:
- CClNO3S
- IUPAC Name:
- [(chlorosulfonyl)imino]methanone
- Test material form:
- gas under pressure: refrigerated liquefied gas
- Details on test material:
- - Name of test material: Chlorosulfonyl isocyanate
Constituent 1
Test animals
- Species:
- rabbit
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 4 hour exposure period.
- Observation period:
- 48 hour observation period.
- Number of animals:
- 6 rabbits were used.
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 4, 24 and 48 hours
- Score:
- 7.9
- Max. score:
- 8
- Reversibility:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The primary irritation index was determined to be 7.9. The test item was considered to be corrosive.
- Executive summary:
A study similar or equivalent to EU Method B.4 and OECD Guideline 404 (Acute Dermal Irritation / Corrosion) was carried out. The shaved and abraded skin of 6 rabbits was exposed to test item for a period of 4 hours. Based on observations after 4, 24 and 48 hours the primary irritation index was determined to be 7.9. The test item was considered to be corrosive.
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