Registration Dossier
Registration Dossier
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EC number: 268-083-8 | CAS number: 68002-70-0 This substance is identified by SDA Substance Name: C16-C22 trialkyl glyceride and SDA Reporting Number: 21-001-00.
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Not available
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature source (documentation insufficient for assessment)
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
- Principles of method if other than guideline:
- Single oral dose of coconut oil was administered to rats to determine the acute oral toxicity potential.
- GLP compliance:
- not specified
- Test type:
- other: no data
- Limit test:
- yes
Test material
- Reference substance name:
- Glycerides, C8-18 and C18-unsatd.
- IUPAC Name:
- Glycerides, C8-18 and C18-unsatd.
- Reference substance name:
- Glycerides, C8-18 and C18-unsatd.
- EC Number:
- 266-946-3
- EC Name:
- Glycerides, C8-18 and C18-unsatd.
- IUPAC Name:
- 266-946-3
- Reference substance name:
- 67701-28-4
- Cas Number:
- 67701-28-4
- IUPAC Name:
- 67701-28-4
- Details on test material:
- - Name of test material (as cited in study report): Coconut oil (CAS N° 8001-31-8, EC N° 232-282-8); under the SDA nomenclature, the name of this substance is ‘Glycerides, C8-18 and C18-unsatd.’
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data
- Doses:
- 26 mL/kg bw (23500 mg/kg bw)
- No. of animals per sex per dose:
- 10 animals
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 23 500 mg/kg bw
- Mortality:
- No mortality
- Clinical signs:
- other: No data
- Gross pathology:
- No data
- Other findings:
- No data
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 of the coconut oil in rats is greater than 23,500 mg/kg bw.
- Executive summary:
In an acute oral toxicity test, 26 mL/kg bw (23,500 mg/kg bw) of coconut oil was orally administered to 10 rats.
No mortality was observed. The oral LD50 of coconut oil in rats can therefore be considered to be greater than 23,500 mg/kg bw. ,
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