Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-016-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- October 5, 1992-December 18, 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Benzene, mono-C10-13-alkyl derivs., distn. residues
- EC Number:
- 284-660-7
- EC Name:
- Benzene, mono-C10-13-alkyl derivs., distn. residues
- Cas Number:
- 84961-70-6
- IUPAC Name:
- 84961-70-6
- Reference substance name:
- Benzene, mono-C10-13-alkyl derivs., distillation residues
- IUPAC Name:
- Benzene, mono-C10-13-alkyl derivs., distillation residues
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Fa. Dr. Karl Thomae GmbH, Biberach
- Age at study initiation: adult
- Weight at study initiation: 2-3 kg
- Housing: singly in stainless steel cages, identified by ear tags
- Diet (e.g. ad libitum): Ssniff K4, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 3 degree C
- Humidity (%): 30-70%
- Air changes (per hr): 15 changes/hr
- Photoperiod (hrs dark / hrs light): 12 hrs light/12 hrs dark
IN-LIFE DATES: From: December 12, 1992 To: December 18, 1992
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- There was one intact skin test site per animal. Each test site was treated with 0.5 mL of undiluted test material.
- Duration of treatment / exposure:
- 4 hrs
- Observation period:
- Observations for dermal irritation and defects occurred at 3/4, 24, 48, and 72 hours, and 6, 8, and 10 days after the occlusion period.
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: dorsal
- Type of wrap if used: Aesculap Favorita II
REMOVAL OF TEST SUBSTANCE
- Washing (if done): washed with warm water
- Time after start of exposure: 4 hrs
SCORING SYSTEM: Draize
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 hrs
- Score:
- 1.25
- Irritant / corrosive response data:
- All animals showed signs of erythema (maximum score of 2) by the 3/4 hr observation. Five of the six animals also showed edema (maximum score of 2) at that reading as well. Erythema and edema persisted through the 72 hr reading, though by the 6 day reading only 2 animals showed signs of erythema, and one animal still showed signs of edema. By the day 8 reading, all signs of erythema and edema had resolved. At the 72 hr observation, one animal display yellowish, and drying and cracking skin. At the 6 day observation, this animal, along with 3 others showed shedding skin. By the 8 day observation, most of these animals still showed shedding skin, though it was healing. By the 10 day observation, all symptoms had resolved.
Any other information on results incl. tables
Results of Skin Irritation Study
Animal |
1 |
2 |
3 |
4 |
5 |
6 |
Erythema |
||||||
¾ hr |
2 |
1 |
2 |
1 |
2 |
2 |
24 hrs |
2 |
2 |
1 |
2 |
2 |
1 |
48 hrs |
2 |
2 |
1 |
1 |
2 |
1 |
72 hrs |
3 |
2 |
1 |
2 |
3 |
1 |
6 days |
2 |
0 |
0 |
0 |
1 |
0 |
8 days |
0 |
0 |
0 |
0 |
0 |
0 |
10 days |
0 |
0 |
0 |
0 |
0 |
0 |
Edema |
||||||
¾ hr |
1 |
1 |
2 |
1 |
1 |
0 |
24 hrs |
1 |
1 |
1 |
1 |
1 |
0 |
48 hrs |
1 |
1 |
0 |
1 |
1 |
0 |
72 hrs |
2 |
1 |
0 |
1 |
1 |
0 |
6 days |
1 |
0 |
0 |
0 |
0 |
0 |
8 days |
0 |
0 |
0 |
0 |
0 |
0 |
10 days |
0 |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The primary irritation index was 1.25 and all symptoms were fully reversible within 14 days. The test substance is not classified as a skin irritant according to EU GHS guidelines.
- Executive summary:
This study examined the potential of the test substance to cause irritation to skin. The test substance was placed on the skin of 6 male rabbits for 4 hrs, and covered with a semi-occlusive patch. After 4 hrs, the test substance was removed with warm water. The animals were scored for signs of edema and erythema according to the Draize scale at 3/4, 24, 48, and 72 hrs. Because symptoms were not fully resolved at the end of 72 hrs, the study was extended through 10 days after exposure. Signs of erythema (maximum score of 2) and edema (maximum score of 2) were seen at the 3/4 hr observation. These symptoms were fully resolved by the day 8 observation. Signs of discoloration, drying and cracking were seen starting at the 72 hr observation. By the day 10 observation, all of these symptoms were resolved as well. The primary irritation index was 1.25, and all symptoms were fully reversible. The test substance is therefore not classified as a skin irritant according to EU GHS guidelines.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)