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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 701-016-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
Benzene, C16-24 alkyl derivatives are also known as High Molecular Weight Linear Alkylbenzenes (HiMo LAB). The substance is a UVCB. Because of their high molecular weight, they are very similar in composition and properties to the heavy alkylate bottoms (HABs), which are the higher boiling point residual co-products in the linear alkylbenzene (LAB) manufacturing process. Based on these structural and functional similarities, data on LAB (CAS no: 67774-74-7), LAB Alkylate Bottoms (CAS no: 85117-41-5), and HAB (CAS no: 84961-70-6) are suitable as supporting studies in case where specific data on the HiMo LAB is lacking.
To assess the skin sensitisation profile of the substance, structral analogue approach was used from Benzene, C10-13-alkyl derivs. (LAB, CAS No: 67774-74-7) and Benzene, mono-C10-13-alkyl derivatives, distillation residues (HAB, CAS No: 84961-70-6).
The study examined the potential of LAB to cause sensitization to skin according to OECD guideline 406. Groups of 20 female guinea pigs were exposed by injection to 20 and 40% test substance. One week later, they were exposed dermally to a solution of 50% test substance. The first challenge was 14 days later, and the animals were exposed to 20% test substance dermally. One week later, a second challenge was done, in which the animals were exposed to 5 and 10% test substance dermally. Animals were scored for skin irritation at 24, 48, and 72 hrs after the last challenge. The 48 hr reading was used to determine sensitization. No signs of dermal irritation were seen at this reading. The test substance in not sensitizing to skin.
The study examined the potential of HAB to cause sensitization to skin according to OECD guideline 406. A group of 10 female guinea pigs were exposed to a concentration of 50% of test substance. 10 female guinea pigs were used as controls. The induction phase consisted of two intradermal injections followed by dermal application. 14 days later, the animals were challenged by dermal application. No signs of irritation were seen in any animals during the challenge phase. The test substance is not sensitising to skin.
Based on the data from supporting analogues, HiMo LAB is considered not sensitising to skin.
Migrated from Short description of key information:
No study on skin sensitisation is available with the substance. Data from LAB (CAS no: 67774-74-7), HAB (CAS no: 84961-70-6) were used to assess the skin sensitisation potential of the substance. The guinea-pig maximization tests were performed to the substances. Based on the woe approach from supporting analogues, the substance is considered not sensitising to skin.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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