Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-807-2 | CAS number: 88-18-6
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The 48-hr EC50 for Daphnia magna was determined to be 3.4 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 3.4 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 2.4 mg/L
Additional information
Reliable (Klimisch 1 or 2) short-term toxicity studies with invertebrates have been conducted for o-tert-butylphenol or the structural analogue, o -sec-butylphenol and are included in this dossier.
Schulz (1995) conducted a reliable (Klimisch 2) GLP compliant study according to OECD 202 methods. The 48-hr acute toxicity of o-tert-butylphenol to Daphnia magna was studied under static conditions. Daphnids were exposed to control and test chemical at nominal concentrations of 0.3, 0.6, 1.3, 2.5, 5.0, and 10 mg/L for 48 hr. Stability of the test substance over the study period was confirmed by photometric analysis. Immobilisation and sublethal effects were observed daily. The 48-hour EC50was reported to be 3.4 mg/L.
McLeese et al (1981) conducted a reliable (Klimisch 2) toxicity study using o-tert-butylphenol.
MOE Japan (1999) conducted a reliable (Klimisch 2) GLP compliant study according to OECD 202 methods. The 48-hr acute toxicity of the structural analogue, o-sec-butylphenol, to Daphnia magna was studied under static conditions. Daphnids were exposed to control and test chemical at nominal concentrations of 1.0, 1.8, 3.2, 5.6, and 10 mg/l for 48 hr. Immobilisation was observed at 48 hours. The 48-hour EC50was reported to be 4.0 mg/L.
McLeese et al (1981) conducted a reliable (Klimisch 2) toxicity study using the structural analogue. The 96-hr acute toxicity of o-sec-butylphenol to the shrimp,Crangon septemspinosa, was studied under static conditions in saltwater. Shrimp were exposed to control and test chemical at nominal concentrations for 96 hr. The 96-hour LC50was reported to be 1.3 mg/L, based on mortality.
Reliable (Klimisch 2) short-term toxicity studies with invertebrates have been conducted for o-tert-butylphenol or the structural analogue, o -sec-butylphenol
and are included in this dossier. The key study, Schulz (1995), provides a 48-hr EC50 of 3.4 mg/L for o-tert-butylphenol for Daphnia magna. Additionally, McLeese et al (1981) provides a 96 -hr EC50 of 2.4 mg/L for o-tert-butylphenol for the saltwater shrimp. Consequently, these values will be taken as the short-term toxicity in aquatic invertebrates endpoint for o-tert-butylphenol.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
