Registration Dossier
Registration Dossier
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EC number: 202-855-7 | CAS number: 100-47-0
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: acute oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1990
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects pharmacologiques du benzonitrile sur le systeme nerveux central
- Author:
- Cheav, S.L., Chalfoun-Mounayar, A., et al.
- Year:
- 1 990
- Bibliographic source:
- Ann. Pharm. Fr., 48, 209-218
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Benzonitrile
- EC Number:
- 202-855-7
- EC Name:
- Benzonitrile
- Cas Number:
- 100-47-0
- Molecular formula:
- C7H5N
- IUPAC Name:
- benzonitrile
- Reference substance name:
- Toluene
- EC Number:
- 203-625-9
- EC Name:
- Toluene
- Cas Number:
- 108-88-3
- Molecular formula:
- C7H8
- IUPAC Name:
- toluene
- Reference substance name:
- Benzaldehyde
- EC Number:
- 202-860-4
- EC Name:
- Benzaldehyde
- Cas Number:
- 100-52-7
- Molecular formula:
- C7H6O
- IUPAC Name:
- benzaldehyde
- Reference substance name:
- Terephthalonitrile
- EC Number:
- 210-783-2
- EC Name:
- Terephthalonitrile
- Cas Number:
- 623-26-7
- Molecular formula:
- C8H4N2
- IUPAC Name:
- terephthalonitrile
- Reference substance name:
- Benzene-1,3-dicarbonitrile
- EC Number:
- 210-933-7
- EC Name:
- Benzene-1,3-dicarbonitrile
- Cas Number:
- 626-17-5
- Molecular formula:
- C8H4N2
- IUPAC Name:
- isophthalonitrile
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- water
- Test material form:
- liquid
Constituent 1
impurity 1
impurity 2
impurity 3
impurity 4
impurity 5
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- single application
- Frequency of treatment:
- single application
Doses / concentrationsopen allclose all
- Dose / conc.:
- 240 mg/kg bw/day (nominal)
- Remarks:
- Basis: actual ingested
- Dose / conc.:
- 480 mg/kg bw/day (nominal)
- Remarks:
- Basis: actual ingested
- Dose / conc.:
- 720 mg/kg bw/day (nominal)
- Remarks:
- Basis: actual ingested
- No. of animals per sex per dose:
- 10
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Based on neuromotor effects, catalepsy and analgesia, it was concluded that benzonitrile could affect catecholaminergic neurones.
- Executive summary:
Based on neuromotor effects, catalepsy and analgesia, it was concluded that benzonitrile could affect catecholaminergic neurones.
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