Registration Dossier
Registration Dossier
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EC number: 202-855-7 | CAS number: 100-47-0
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Remarks:
- secondary literature; collection of data; human tox data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Monographs on Fragrance raw Materials. Benzonitrile
- Author:
- Opdyke, D. L. J.
- Year:
- 1 979
- Bibliographic source:
- Food. Cosmet. Toxicol. 17 Suppl.
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- maximization test according to Kligman, 1966; Kligman&Epstein, 1975
- GLP compliance:
- no
Test material
- Reference substance name:
- Benzonitrile
- EC Number:
- 202-855-7
- EC Name:
- Benzonitrile
- Cas Number:
- 100-47-0
- Molecular formula:
- C7H5N
- IUPAC Name:
- benzonitrile
- Reference substance name:
- Toluene
- EC Number:
- 203-625-9
- EC Name:
- Toluene
- Cas Number:
- 108-88-3
- Molecular formula:
- C7H8
- IUPAC Name:
- toluene
- Reference substance name:
- Benzaldehyde
- EC Number:
- 202-860-4
- EC Name:
- Benzaldehyde
- Cas Number:
- 100-52-7
- Molecular formula:
- C7H6O
- IUPAC Name:
- benzaldehyde
- Reference substance name:
- Terephthalonitrile
- EC Number:
- 210-783-2
- EC Name:
- Terephthalonitrile
- Cas Number:
- 623-26-7
- Molecular formula:
- C8H4N2
- IUPAC Name:
- terephthalonitrile
- Reference substance name:
- Benzene-1,3-dicarbonitrile
- EC Number:
- 210-933-7
- EC Name:
- Benzene-1,3-dicarbonitrile
- Cas Number:
- 626-17-5
- Molecular formula:
- C8H4N2
- IUPAC Name:
- isophthalonitrile
- Reference substance name:
- Water
- EC Number:
- 231-791-2
- EC Name:
- Water
- Cas Number:
- 7732-18-5
- Molecular formula:
- H2O
- IUPAC Name:
- water
- Test material form:
- liquid
Constituent 1
impurity 1
impurity 2
impurity 3
impurity 4
impurity 5
Method
- Type of population:
- not specified
- Controls:
- no details reported
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- SYMPTOMS
- Frequency, level, duration of symptoms observed: no symptoms observed
NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: none
- Number of subjects with negative reactions: all (35 of 35 and 27 out of 27)
- Number of subjects with equivocal reactions: none
- Number of subjects with irritating reactions: none
RESULT OF CASE REPORT: no sensitisation reactions
Any other information on results incl. tables
The material was tested at a concentration of 2% in petrolatum and produced no sensitisation reactions (Epstein, 1977). The material was retested (same concentration) in mixed panel it produced no sensitisation reactions (Epstein, 1977).
Applicant's summary and conclusion
- Conclusions:
- Benzonitrile was tested at a concentration of 2% in petrolatum and produced no sensitisation reactions (Epstein, 1977). The material was retested (same concentration) in mixed panel it produced no sensitisation reactions (Epstein, 1977).
- Executive summary:
Benzonitrile was tested at a concentration of 2% in petrolatum and produced no sensitisation reactions (Epstein, 1977). The material was retested (same concentration) in mixed panel it produced no sensitisation reactions (Epstein, 1977).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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