Registration Dossier
Registration Dossier
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EC number: 224-030-0 | CAS number: 4170-30-3
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Absorption, Distribution, Metabolism and Excretion Summary
Limited information was available on the absorption, distribution, metabolism and excretion of crotonaldehyde. Crotonaldehyde has been analyzed by in vitro, and oral and intravenous (IV) administration in male rats for absorption, distribution, metabolism and excretion. Crotonaldehyde has been experimentally demonstrated to not be bioaccumulative. Up in vitro incubation with stomach content, [14C] crotonaldehyde of > 96% purity was fairly stable (94% recovered unchanged and 5% bounded to particulate material) however, it was not stable with plasma enzymes (recovered intact after 5 min). Metabolism data of crotonaldehyde via oral administration showed that greater than 90% was absorbed and within 12 hours of dosing up 78% was excreted in breath and urine. After injecting rats with crotonaldehyde, within 6 hours, 31% of the dose was excreted as 14CO2 in breath and 17% as unknown metabolites; after 72 hours, approximately 40% was excreted in the breath and 50% in urine. Less that 1% was found in the feces. Elimination in the tissues and blood was rapid with half lives calculated as 1hour or less. This was followed by a much slower elimination of the last 10% of the dose which occurred with half-lives of 2.5 days or longer. Also, authors suggest that crotonaldehyde reacts rapidly with glutathione followed by hydrolysis and it is converted into 3-hydroxy-1-methylpropylmercapturic acid in rats which is excreted in the urine. Based on the available data, the two major routes of excretion indentified following oral or IV administration were the breath and urine.
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