1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)

Endpoint summary

Description of key information

Short description of key information on bioaccumulation potential result: 
Toxicokinetics of Octopirox were investigated in rats and dogs after dermal, oral and intravenous administration. Indications of a bioaccumulative 
potential or biopersistenct behaviour were not observed. Oral absorption is incomplete and excretion is rapid and practically complete within 1 to 7 days after application. Differences between species, sexes and/or various routes of exposure in the toxicokinetic behaviour do not exist.
Short description of key information on absorption rate: 
Dermal absorption and excretion of Octopirox were investigated in rats following exposure by intubation, injection or application to the skin by 
comparing blood levels after intubation and dermal administration. Whether given by mouth, injection or application to the skin, Octopirox was 
excreted essentially unchanged. The dermal penetration potential of Octopirox was low. Based on the results of these studies systemic toxic effects of 
Octopirox due to absorption through the skin is negligible.

Key value for chemical safety assessment

Absorption rate - dermal (%):

1

Additional information

Toxicokinetics of Octopirox were investigated in rats and dogs after dermal, oral and intravenous administration. Based on all available data, Octopirox does not exhibit a conspicuous kinetic behavior in the sense of accumulative and/or delyed effects with regard to the individual parameters absorption including skin penetration, distribution, metabolism and excretion. In the turnover experiments, both sexes of test animals excreted the test material predominantly via faeces and only to much smaller amounts in the urine. Octopirox was excreted essentially unchanged and elimination occurred rapidly and virtually completely. The possibility of systemic effects of Octopirox due to absorption through the skin is negligible.

Discussion on bioaccumulation potential result:

The results of the available kinetic studies give no reason to anticipate unusual characteristics with regard to the toxicokinetic profile of Octopirox.

Discussion on absorption rate:

The skin penetration experiments with Octopirox in rats revealed that this compound has only limited potential for pentration which, however, is considered to be very low. A bioaccumulative potential was not observed. In the penetration and turnover experiments, both sexes of rats given Octopirox by three different routes of administartion excreted large amounts of the compound in the faeces and only much smaller amounts in the urine. From the available data it can be concluded that Octopirox is rapidly and virtually completely removed from the body.