Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 272-574-2 | CAS number: 68890-66-4
Endpoint summary
Administrative data
Description of key information
Octopirox was tested for skin and eye irritation in rabbits using both, technical pure material as well as diluted material using test-concentrations reflecting practical use conditions. The dermal irritative potential of Octopirox preparations was additionally investigated in human volunteers. Based on the available study results from the animal experiments, pure Octopirox must be regarded as an irritant to skin in animals. However, in concentrations representing practical use conditions, Octopirox exhibits a good skin tolerance in animals as well as in human volunteers. Pure Octopirox is severely irritating to eyes, but exhibits a good eye mucous membran tolerability as well when tested at concentrations reflecting practical use conditions.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Testing of Octopirox for skin and eye irritating properties have revealed that pure Octopirox is a skin and eye irritant. However, when tested at concentrations reflecting practical use conditions, Octopirox exhibited a good skin tolerance without significant irritating potential in animals as well as in human volunteers and a good eye mucous membran tolerability in animals.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: highly irritating
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Based on the available test results, pure Octopirox, this substance has to be classified as irritating to skin and eye.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
