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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
No data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
yes
Remarks:
Lack of details on test substance and environmental conditions of animals. Only four animals per dose used (guideline requires 5).
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-(trimethoxysilyl)propiononitrile
EC Number:
219-764-3
EC Name:
3-(trimethoxysilyl)propiononitrile
Cas Number:
2526-62-7
Molecular formula:
C6H13NO3Si
IUPAC Name:
3-(trimethoxysilyl)propanenitrile
Constituent 2
Reference substance name:
3-(trimethoxysilyl)propionitrile
IUPAC Name:
3-(trimethoxysilyl)propionitrile

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: 2-3 kg
- Fasting period before study: No
- Housing: No data
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: No data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data

IN-LIFE DATES: No data

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: Trunk
- % coverage: No data
- Type of wrap if used: Impervious sheeting

REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes
- Time after start of exposure: 24 hours

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 16 and 8 ml/kg
- Constant volume or concentration used: yes, undiluted
Duration of exposure:
24 Hours
Doses:
Males: 16 ml/kg bw.
Females: 16 and 8 ml/kg bw.
No. of animals per sex per dose:
Four
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: after one hour, 7 days and 14 days.
- Necropsy of survivors performed: yes
- Other examinations performed: body weights (0, 7 and 14 days) and clinical signs.
Statistics:
The LD50 was calculated using the moving averages method and are based on a 14 -day observation period.

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 16 mL/kg bw
Based on:
test mat.
Mortality:
The maximum dermal application of the test substance (16 ml/kg bw) lead to one death in male rabbits and no deaths in female rabbits. Therefore, an LD50 could not be determined.
Clinical signs:
other: None
Gross pathology:
At necropsy there were signs of lung infection in the males that died before the end of the 14 day observation period: lung and upper thoracic cavity fluid-filled and covered with yellow puss. Some males and females were found to have red patches in the trachea and lungs.
Other findings:
Capillary injection, erythema, oedema were observed one day after exposure in male and female animals. By 7 and 14 days scabs and desquamation were observed in females only.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In an acute dermal toxicity study conducted using a protocol similar to OECD 402, but not to GLP (reliability score 2), the dermal LD50 for 3-(trimethoxysilyl)propiononitrile was greater than 16 ml/kg bw (15520 mg/kg bw, based on relative density of 0.97 g/cm3) in rabbits.