Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1987-04-01 to 1987-05-24
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study (OECD), non-GLP but internally audited.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Pyruvaldehyde
EC Number:
201-164-8
EC Name:
Pyruvaldehyde
Cas Number:
78-98-8
Molecular formula:
C3H4O2
IUPAC Name:
2-oxopropanal

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Dr. K. Thomae GmbH, 7950 Biberach, Germany
- Age at study initiation: not specified
- Weight at study initiation: "comparable" (+/- 20% of the mean weight)
- Fasting period before study: 16 h
- Housing: Stainless steel wire mesh cage (Type DK III)
- Diet: ad libitum (except during fasting)
- Water: ad libitum
- Acclimation period: at least one week

ENVIRONMENTAL CONDITIONS
- Temperature: 20 - 24°C
- Humidity: 30 - 70 %
- Air changes: not specified ("fully air conditioned")
- Photoperiod: 12 hrs dark / 12 hrs light

IN-LIFE DATES: From 1987-04-01 to 1987-05-24

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
CMC (carboxymethyl cellulose)
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 50, 31.6, 21.5, 10, 4.64 mg / mL (w/v)
- Amount of vehicle: 0.5% CMC in water
- Justification for choice of vehicle: "Aqueous formulation corresponds to the physiological medium"

MAXIMUM DOSE VOLUME APPLIED: 10 mL / kg bw

Doses:
1500, 948, 645, 300, 139 mg/kg bw, calculated (30%) from original dosages:
5000, 3160, 2150, 1000, 464 mg/kg bw
No. of animals per sex per dose:
5 males and 5 females
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations:
a) signs and syptoms: several times on the day of application, at least once daily on workdays thereafter;
b) moribund or dead animals: twice daily on workdays and once daily on public holidays
- Frequency of weighing: Once at beginning of test, d6 or d7, d13
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Statistics:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 1 380 mg/kg bw
Based on:
test mat.
Remarks on result:
other: interpolated (from 30% solution)
Mortality:
5000 mg/kg bw: males: 2 within one day; females: 5 within one day
3160, 2150, 1000 and 464 mg/kg bw: no mortality
Clinical signs:
other: Dyspnea, apathy, abnormal position, staggering, atonia, paresis, piloerection, cyanosis, poor general state
Gross pathology:
Perished males and females: General congestion. Stomach: mucosa of glandular stomach reddened, partly white
Sacrificed males and females: no pathologic findings
Other findings:
No

Applicant's summary and conclusion