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EC number: 238-289-2 | CAS number: 14338-82-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with GLP certificate
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
- Version / remarks:
- acc. to 2004/73/EC
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Dibutyl methylenedithiodi(acetate)
- EC Number:
- 238-289-2
- EC Name:
- Dibutyl methylenedithiodi(acetate)
- Cas Number:
- 14338-82-0
- Molecular formula:
- C13H24O4S2
- IUPAC Name:
- butyl 2-({[(2-butoxy-2-oxoethyl)sulfanyl]methyl}sulfanyl)acetate
- Test material form:
- other: liquid
- Details on test material:
- Lot#: 20704
Assay GC-FID: 96.9 area%
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- other: CBA/CaBkl and CBA/CaOlaHsd
- Sex:
- female
- Details on test animals and environmental conditions:
- animals were house individually housed in PP cages with softwood woodflakes.
Acclimatisation period of 5 days
Free access to tap water and food (certified rat and mouse Diet) throuout the study
Temperature between 19 and 25°C, humidity between 30 and 70% rel.
Light cycle 12/12 h
Air exchange appr. 15 / h
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 25 and 50% in vehicle, 100%
- No. of animals per dose:
- 4
- Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
- Positive control results:
- Sensitivity and reliability of the test was assessed by use of alpha-hexylcinammaldehyd which is known for a positive reaction in CBA mice. (Safepharm Study 0039/0944)
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: S.I < 1.45 for concentrated test material, conclusion: no stimulation
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: see Remark
- Remarks:
- Test mat conc dpm dpm/Node Stimulation index Result %v/v in vehicle 0 (vehicle) 6268.52 783.57 n.a. n.a. 25 6661.75 832.72 1.06 negative 50 9112.35 1139.04 1.45 negative 100 8885.62 1110.70 1.42 negative
Any other information on results incl. tables
The test item was assayed at three concentrations of 25, 50 and 100%.
Each female mousewas treated by topical application with the selected solution to entire dorsal surface of each ear
once daily over three consecutive days.
Five days after the first topical application treatment all mice were injected intravenous with 3H-methyl thymidine.
Approximately 5 hours after 3H-methyl thymidine injection all mice were sacrificed and the draining auricular lymph nodes were excised, in order to prepare single cell suspension of the lymph node cells.
The 3 H-methyl thymidine-incorporation was measured in a Beckman LS6500 counter and expressed as the number of disintegrations per minute (DPM). Determination of radioactivity was performed individually for each animal. The proliferation response of lymph node cells was calculated as the ratio of 3H-methyl thymidine incorporation into lymph nodecells of test group animals relative to that recorded for control group animals. A stimulation index, ratio of test substance/vehiclecontrol, was calculated for each concentration.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material was considered to be a non-sensitizer under the conditions of the test.
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