Registration Dossier
Registration Dossier
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EC number: 700-080-3 | CAS number: 752225-55-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 955
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 24 hrs. covered contact
- Principles of method if other than guideline:
- A group of four male albino New Zealand strain rabbits, 3 to 5 months of age and averaging 2.5 kg were immobilized during the 24-hour skin contact period with 20 ml/kg bw EP-302. The material remained in place during the 24-hour contact period with "Vinylite" sheeting. After the 24-hour period the sheeting was removed and the animals were caged for the remainder of the 14-day observation period. Thompson's method for calculating the LD50 was used.
- GLP compliance:
- no
Test material
- Reference substance name:
- Soybean oil, epoxidized
- EC Number:
- 232-391-0
- EC Name:
- Soybean oil, epoxidized
- Cas Number:
- 8013-07-8
- IUPAC Name:
- 8013-07-8
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
Administration / exposure
- Type of coverage:
- other: 24 hours contact
- Vehicle:
- not specified
- Duration of exposure:
- 24h
- Doses:
- 20 ml/kg bw
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 20 mL/kg bw
- Mortality:
- no
- Clinical signs:
- other: no
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- A dosage of 20 ml/kg of the undiluted compound resulted in survival of all four rabbits. No particular damage other than transient erythema resulted.
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