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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1955

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 24 hrs. covered contact
Principles of method if other than guideline:
A group of four male albino New Zealand strain rabbits, 3 to 5 months of age and averaging 2.5 kg were immobilized during the 24-hour skin contact period with 20 ml/kg bw EP-302. The material remained in place during the 24-hour contact period with "Vinylite" sheeting. After the 24-hour period the sheeting was removed and the animals were caged for the remainder of the 14-day observation period. Thompson's method for calculating the LD50 was used.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Soybean oil, epoxidized
EC Number:
232-391-0
EC Name:
Soybean oil, epoxidized
Cas Number:
8013-07-8
IUPAC Name:
8013-07-8

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male

Administration / exposure

Type of coverage:
other: 24 hours contact
Vehicle:
not specified
Duration of exposure:
24h
Doses:
20 ml/kg bw
No. of animals per sex per dose:
4
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 20 mL/kg bw
Mortality:
no
Clinical signs:
no

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
A dosage of 20 ml/kg of the undiluted compound resulted in survival of all four rabbits. No particular damage other than transient erythema resulted.

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