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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP non-guideline, available as unpublished report, minor restrictions in design and/or reporting but otherwise adequate for assessment.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1970
Report date:
1970
Reference Type:
other: English translation (summary)
Title:
Unnamed
Year:
2005
Report date:
2005

Materials and methods

Principles of method if other than guideline:
According to BASF-internal standard. The test substance (ca. 0.5 g) was applied to a 2.5 x 2.5 cm application site of white Vienna rabbits for 1 min, 5 min, 15 min and 20 h under occlusive conditions. The skin was left intact. Animals were observed for 8 days and skin changes were observed. Findings were recorded after 24 hours and at the end of the observation period. Findings were graded as described in OECD test guideline 404.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Butyl chloroformate
EC Number:
209-750-5
EC Name:
Butyl chloroformate
Cas Number:
592-34-7
Molecular formula:
C5H9ClO2
IUPAC Name:
butyl carbonochloridate
Details on test material:
- Name of the test substance used in the study report: n-Butylchlorkohlensaeureester, Chloroformic acid butyl ester

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
- Weight at study initiation: Male animal 3.24 kg, Female animal 2.53 kg

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
other: untreated skin of the same animal
Amount / concentration applied:
Undiluted
Duration of treatment / exposure:
1 min, 5 min, 15 min, 20 h
Observation period:
8 days
Number of animals:
2
Details on study design:
- The test substance was washed off after the appropriate exposure time with Lutrol/water (1:1)

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal: #1 and #2
Time point:
other: 24 h
Score:
3
Max. score:
4
Reversibility:
not fully reversible within: 8 days
Remarks on result:
other: 5 min, 15 min and 20 hr exposure. Necrosis after 8 days
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 24 h
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 8 days
Remarks on result:
other: 5 min, 15 min and 20 hr exposure. Induration after 8 days
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 24 h
Score:
0
Max. score:
4
Remarks on result:
other: 5 min and 15 min
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 24 h
Score:
3
Max. score:
4
Reversibility:
fully reversible within: 8 days
Remarks on result:
other: 20 hr exposure. Transverse folds after 8 days
Irritant / corrosive response data:
- 1 minute exposure: After 24 hours marked erythema was observed in both animals. These effects were not reversible within 8 days. In addition marked scaling was observed on both animals after 8 days.
- 5 and 15 minute exposure: After 24 hours marked erythema was observed in both animals and slight edema in animal #1. The observed erythema was not reversible within 8 days. In addition necrosis was observed in animal #1 and hardening of the skin in both animals.
- 20 hour exposure: After 24 hours marked erythema was observed in both animals and slight edema in animal #1 and strong edema in animal #2. The observed erythema was not reversible within 8 days. In addition necrosis was observed in both animals and transverse folds were present in the skin in both animals.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information