Registration Dossier
Registration Dossier
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EC number: 209-750-5 | CAS number: 592-34-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP non-guideline, available as unpublished report, minor restrictions in design and/or reporting but otherwise adequate for assessment.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
- Reference Type:
- other: English translation (summary)
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
- Principles of method if other than guideline:
- According to BASF-internal standard. The eye irritating potential of the test substance was examined in 2 rabbits. The animals were exposed to about 0.05 mL of the test substance. Effects were scored according to the method of Draize. Observations were made after 1, 24 hour and 8 days.
- GLP compliance:
- no
Test material
- Reference substance name:
- Butyl chloroformate
- EC Number:
- 209-750-5
- EC Name:
- Butyl chloroformate
- Cas Number:
- 592-34-7
- Molecular formula:
- C5H9ClO2
- IUPAC Name:
- butyl carbonochloridate
- Details on test material:
- - Name of the test substance used in the study report: n-Butylchlorkohlensaeureester, Chloroformic acid butyl ester
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- - Weight at study initiation:Animal #1: 2.7 kg, animal #2: 2.48 kg
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: NaCl treated eye of the same animal
- Amount / concentration applied:
- 0.05 mL
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 8 d
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- The test substance was not washed off.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- animal: #1 and #2
- Time point:
- other: 24 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- other: after 8 days staphyloma, injected vessels
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: #1 and #2
- Time point:
- other: 24 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 8 days
- Irritant / corrosive response data:
- After 1 hour, marked redness and corneal opacity was observed in both animals. Marked chemosis in animal #1 and severe chemosis in animal #2 was noted.
After 24 hours, marked chemosis and corneal opacity was observed in both animals. Hemorrhages were also observed in both animals. In addition iritis was present in both animals
After 8 days: Slight redness and slight to marked corneal opacity present in both animals. In addition, staphyloma and ingrowing vessels were observed in both animals.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
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