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EC number: 203-892-1 | CAS number: 111-65-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Adopted according to OECD SIDS (public available peer reviewed source) and respective study summary. The original source is not available and has not been reviewed.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- n-octane and n-nonane induced alterations in xenobiotic metabolising enzyme activities and lipid peroxidation of rat liver.
- Author:
- Khan, S. et al.
- Year:
- 1 980
- Bibliographic source:
- Toxicology 16: 239-245
- Reference Type:
- secondary source
- Title:
- OECD SIDS - Category: C7-C9 Aliphatic hydrocarbon solvents
- Author:
- IHSC, American Chemistry Council
- Year:
- 2 009
- Bibliographic source:
- SIDS Initial Assessment Report For SIAM 30 Paris, 20-23 April 2010, drafted by members of the IHSC and reviewed by the U.S. Environmental Protection Agency (EPA), October 28, 2009
- Report date:
- 2009
Materials and methods
- Principles of method if other than guideline:
- Purpose of the study was to evaluate enzyme activity and potential for hepatotoxicity. Animals were treated with octane for 2 or 7 days by intraperitoneal injections.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Octane
- EC Number:
- 203-892-1
- EC Name:
- Octane
- Cas Number:
- 111-65-9
- Molecular formula:
- C8H18
- IUPAC Name:
- octane
- Details on test material:
- - Name of test material (as cited in study report): n-octane
- Analytical purity: 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 2 or 7 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1 mL/kg (approx. 703 mg/kg octane)
- No. of animals per sex per dose:
- 6
- Control animals:
- yes
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Since only a single dose was administered it is not possible to derive a NOAEL.
Actual dose received by dose level: 1.0 mL/kg Toxic response/effects by dose level: After 2 and 7 day treatment with 1.0 mL/kg of n-octane by intraperitoneal injection, 50-80% reduction in specific activities of benzo(a)pyrene hydroxylase, benzphetamine - N-demethylase, p-nitroanisole -o-demethylase and glutathione -S-transferase were observed. Cytochrome P450 (31%) and total (31%) and free (49%) sulfhydryl content of the liver also decreased significantly. A 2 to 3-fold increase in liver lipid peroxidation was observed with exposure for 2 or 7 days to n-octane. n-Octane significantly affected the biotransformation mechanisms of liver microsomes.The toxicological implications of these observations require further study.
Similar effects were observed for n-nonane.
Applicant's summary and conclusion
- Conclusions:
- n-Octane administered at only 1.0 mL/kg/day intraperitoneally for 2 or 7 days resulted in decreases in levels of hepatic xenobiotic metabolizing enzymes and increases in liver lipid peroxidation.
- Executive summary:
n-Octane administered at only 1.0 mL/kg/day intraperitoneally for 2 or 7 days resulted in decreases in levels of hepatic xenobiotic metabolizing enzymes and increases in liver lipid peroxidation.
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