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EC number: 203-892-1 | CAS number: 111-65-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Adopted according to OECD SIDS (public available peer reviewed source) and respective study summary. The original source is not available and has not been reviewed.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Hepatotoxicity in albino rats exposed to n-octane and n-nonane.
- Author:
- Khan, S. and Pandya, K.
- Year:
- 1 985
- Bibliographic source:
- J Appl Toxicol 5: 64-68
- Reference Type:
- publication
- Title:
- Effect of n-octane and n-nonane administration on alkaline phosphatase activity in tissues of female rats.
- Author:
- Pandya, K. and Khan, S.
- Year:
- 1 982
- Bibliographic source:
- Biochem Pharmacol 31: 201-203
- Reference Type:
- secondary source
- Title:
- OECD SIDS - Category: C7-C9 Aliphatic hydrocarbon solvents
- Author:
- IHSC, American Chemistry Council
- Year:
- 2 009
- Bibliographic source:
- SIDS Initial Assessment Report For SIAM 30 Paris, 20-23 April 2010, drafted by members of the IHSC and reviewed by the U.S. Environmental Protection Agency (EPA), October 28, 2009
- Report date:
- 2009
Materials and methods
- Principles of method if other than guideline:
- Purpose of the study was to evaluate enzyme activity and potential for hepatotoxicity. Animals were treated with octane for 2 or 7 days by intraperitoneal injections.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Octane
- EC Number:
- 203-892-1
- EC Name:
- Octane
- Cas Number:
- 111-65-9
- Molecular formula:
- C8H18
- IUPAC Name:
- octane
- Details on test material:
- - Name of test material (as cited in study report): n-octane
- Analytical purity: 99%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 2 or 7 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1 mL/kg (approx. 703 mg/kg octane)
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Since only a single dose was administered it is not possible to derive a NOAEL.
Actual dose received by dose level by sex: 1.0 ml/kg Toxic response/effects by dose level: Statistically significant decreased activity in serum acetylcholinesterase and carboxylesterase were observed with an increase in aldolase after 2 and 7 days of treatment. After 7 days, a significant decrease in albumin (41%) total protein 34%) and total (42%) and esterified (60%) cholesterol was observed for n-octane. Free cholesterol was also increased after 7 days but nucleic acid content was not affected. Decreases in serum actylcholinesterase activity and albumin content may result from disturbances in secretory mechanism due to liver cell necrosis as suggested by the decrease in serum carboxylesterase. Changes in total and esterified cholesterol in serum and in hepatic free cholesterol suggest alteration in the liver esterification process. In an earlier publication by Pandya and Khan, 1980, administration of 1.0 mL/kg n-octane for 2 or 7 days resulted in increased alkaline phosphatase activity of liver, spleen and bone marrow. A single dose of hydrocarbon induced increases in spleen alkaline phosphatase lasting up to 42 days, while pretreatment with a protein synthesis inhibitor (cyclohexamide or ethionine) prevented the increase in alkaline phosphatase in liver and spleen.
Similar effects were observed for n-nonane.
Applicant's summary and conclusion
- Conclusions:
- n-Octane administered at only 1.0 mL/kg/day intraperitoneally for 2 or 7 days induced alterations in hepatic and serum enzymes and in concentrations of serum and liver lipids but did not alter nucleic acid content of liver cells.
- Executive summary:
n-Octane administered at only 1.0 mL/kg/day intraperitoneally for 2 or 7 days induced alterations in hepatic and serum enzymes and in concentrations of serum and liver lipids but did not alter nucleic acid content of liver cells.
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