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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

The Yokohoma Laboratories study was carried out to the highest quality standards and delivered the lowest LC50 for fish.. 

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
20.6 mg/L

Additional information

A full discussion on the justification on read-across of data for the 4,4´-isomer of MDA for oligomeric MDA in the scope of REACH is presented in section 7.6 of this CSR.

The Yokohoma Laboratories study is highly detailed and was given a reliability of one because of compliance with GLP and inclusion of certificate. The 96h LC50 value of 20.6mg/l indicates that 4,4'-MDA has some toxicity to fish, though results elsewhere confirm that for 4,4'-MDA fish are not the most sensitive species of the three trophic levels of the base-set (fish, daphnia and algae).