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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

Yokohama Laboratories (Mitsubishi 2002) have provided a fully detailed high quality report.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
0.005 mg/L

Additional information

A full discussion on the justification on read-across of data for the 4,4´-isomer of MDA for oligomeric MDA in the scope of REACH is presented in section 7.6 of this CSR.

This study was carried out according to GLP (certificate included) and in which all described parameters are closely comparable to the standard OECD Guideline 211 method. The 21d NOEC value of 0.00525 mg/l indicates that MDA is toxic to invertebrates. The results confirm that for 4,4'-MDA invertebrates are the most sensitive species of the three trophic levels of the base set (fish, daphnia and algae). Therefore, this NOEC value may be used to derive a PNECaqua value.