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EC number: 922-551-4 | CAS number: 1187440-66-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-10-27 to 2008-11-06
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- not applicable
- Principles of method if other than guideline:
- not concerned
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
PHYSICO-CHEMICAL PROPERTIES
- Melting point: 70-75°C
- Boiling point: >300°C
- Vapour pressure: 6.66 x 10-5 Pa.
- Water solubility (under test conditions): <1mg/L
OTHER PROPERTIES (if relevant for this endpoint)
- Results of test for ready biodegradability: not considered as ready biodegradable - Analytical monitoring:
- no
- Vehicle:
- yes
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- TEST ORGANISM
- Common name: Pseudokirchnerella subcapitata (reported as Raphidocelis subcapitata)
- Strain: CCAP 278, 4
- Method of cultivation: culltivated in freswater in darkness
ACCLIMATION
- Acclimation period: 4 days
- Culturing media and conditions (same as test or not):yes
- Any deformed or abnormal cells observed: after the 4 days of acclimatation the cells are observed under microscop (meaured and morphology analysing) - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
- Post exposure observation period:
- After each 24h period the concentration of Algae was controled by particle counter
- Test temperature:
- 21-25°C +- 20°C
- pH:
- between 6.9 and 7.9
- Nominal and measured concentrations:
- 1; 10 ; 100mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: lfask erlenmeyer (250ml)
- Initial cells density: 10000 algues at the start of the study
- No. of organisms per vessel:10000 per erlenmeyer
- No. of vessels per concentration (replicates):3
- No. of vessels per control (replicates):6
-
GROWTH MEDIUM
- Standard medium used: yes
OTHER TEST CONDITIONS
- Sterile test conditions: no
- Adjustment of pH:no
- Photoperiod:continuous
- Light intensity and quality:4440 lux -8880
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Determination of cell concentrations: electronic particle counter
- Range finding study
- Test concentrations: 1; 10 ; 100 mg/L
- Results used to determine the conditions for the definitive study:OEDCD guideline 23 - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Results with reference substance (positive control):
- the latest test (june 2008) gives an result of EC50(72h)=0.69mg/L
- Reported statistics and error estimates:
- LOD =0.015mg/L
LOQ=0.05mg/L - Validity criteria fulfilled:
- yes
- Conclusions:
- EC50(72h)>100mg/L in a limit test condition
- Executive summary:
Toxicity of the test item LCE07105 was performed on the freshwater unicellular green algae "Pseudokirchneriella subcapitata" according to the OECDE 201 guideline (screening test). Results obtained show a slight toxicity of the test item with an inhibition of the average specific growth rate in comparison to the control <50% at the highest concentration of 100mg/L. For the reason, the EC50(0-72h) is superior to the highest tested concentration. In order to control and confirm the test item solubilisation and its stability throughout the study, an analysis of the test solution was performed at the 100mg/L test item concentration and in the filtered control: Total phosphorus was chosen as tracer and was analyzed at the start and the end of the study.
Nominal test item concentration in mg/L total [P] at 0h at 72h filtered control
<LOD <LOD 100mg/L detected <0.056mg/L(indicative value: 0;046mg/L) detected 0.056mg/L(indicative value: 0;046mg/L)
Reference
Toxicity of the test item LCE07105 was performed on the freshwater unicellular green algae "Pseudokirchneriella subcapitata" according to the OECDE 201 guideline (screening test). Results obtained show a slight toxicity of the test item with an inhibition of the average specific growth rate in comparison to the control 50% at the highest concentration of 100mg/L. For the reason, the EC50(0-72h) is superior to the highest tested concentration. In order to control and confirm the test item solubilisation and its stability throughout the study, an analysis of the test solution was performed at the 100mg/L test item concentration and in the filtered control: Total phosphorus was chosen as tracer and was analyzed at the start and the end of the study.
Nominal test item concentration in mg/L |
total [P] |
|
|
at 0h |
at 72h |
filtered control |
|
|
100mg/L |
detected 0.056mg/L(indicative value: 0;046mg/L) |
detected 0.056mg/L(indicative value: 0;046mg/L) |
Description of key information
Toxicity of the registered substance was performed on the freshwater unicellular green algae "Pseudokirchneriella subcapitata" according to the OECDE 201 guideline (screening test). The EC50(0-72h) is superior to the highest tested concentration (100 mg/L).
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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