2,2-bis(hydroxymethyl)butanoic acid

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

activated sludge respiration inhibition testing

Type of information:

other: SNIF Report

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Qualifier:

according to guideline

Guideline:

other: 87/302/EWG, S.118

Qualifier:

according to guideline

Guideline:

OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test

GLP compliance:

yes

Test type:

other: aerobic

Total exposure duration:

3 h

Key result

Duration:

3 h

Dose descriptor:

NOEC

Effect conc.:

320 mg/L

Key result

Duration:

3 h

Dose descriptor:

IC50

Effect conc.:

699 mg/L

Executive summary:

The testing of activated sludge in respiration inhibition test according to OECD 209 guideline under GLP condition show inhibition after 3h of exposure as IC 50= 699 mg/L. The no observed effect concentration after 3 h of exposure was established as NOEC = 320 mg/L.

Description of key information

Activated Sludge, Respiration Inhibition Test test was performed according toOECD Guideline 209. Inhibitory effects on the respiration of activated sewage sludge after 3 hours of exposure at the test concertation of 100mg/L was not observed. The no observed effect concertation was established as NOEC = 100 mg/L and the IC 50 was established as more than 100 mg/L. The test was performed according to OECD 209 guideline under GLP condition.

Key value for chemical safety assessment

EC50 for microorganisms:

100 mg/L

EC10 or NOEC for microorganisms:

100 mg/L