Registration Dossier
Registration Dossier
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EC number: 406-760-3 | CAS number: 42221-52-3 2,3,4,5-TETRACHLORBENZOYLCHLORID
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EWG, B.1
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,3,4,5-tetrachlorobenzoylchloride
- EC Number:
- 406-760-3
- EC Name:
- 2,3,4,5-tetrachlorobenzoylchloride
- Cas Number:
- 42221-52-3
- Molecular formula:
- C7HCl5O
- IUPAC Name:
- 2,3,4,5-tetrachlorobenzoyl chloride
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- other: rat, HanIbm:WIST (SPF)
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: Olivenöl
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 996 mg/kg bw
- 95% CL:
- 769 - 1 316
- Remarks on result:
- other: Slope of the mortality curve: 3.1
- Mortality:
- Male: 500 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 750 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 1
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 500 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 750 mg/kg bw; Number of animals: 5; Number of deaths: 3
Female: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 5 - Clinical signs:
- other: Signs of toxicity related to dose levels: Alle Sterbefälle geschahen in den ersten zwei Beobachtungstagen. In allen Dosisgruppen wurde Sedation, Kauerstellung, unkoordinierte Bewegungen und Dyspnoe beobachtet. "ENGLISH" All of the mortalities occurred in
- Gross pathology:
- Effects on organs:
Bei den überlebenden Tieren wurde keine makroskopischen
Veränderungen beobachtet.
Bei den toten Tieren beobachtete man bei:
750 mg/kg: 2 von 3 Tieren hatten eine dunkelrot
verfärbte Lunge.
1000 mg/kg: 4 von 6 Tieren hatten eine dunkelrot
verfärbte Lunge.
2000 mg/kg: 2 von 9 Tieren hatten eine dunkelrot
verfärbte Lunge.
"ENGLISH"
No macroscopic changes were observed among the surviving
animals. The following observations were made in the case of
the deceased animals.
750 mg/kg: 2 out of 3 animals had a dark-red discoloured
lung.
1000 mg/kg: 4 out of 6 animals had a dark-red discoloured
lung.
2000 mg/kg: 2 out of 9 animals had a dark-red discoloured
lung.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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