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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1991
Report date:
1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 84/449/EWG, B.1
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,3,4,5-tetrachlorobenzoylchloride
EC Number:
406-760-3
EC Name:
2,3,4,5-tetrachlorobenzoylchloride
Cas Number:
42221-52-3
Molecular formula:
C7HCl5O
IUPAC Name:
2,3,4,5-tetrachlorobenzoyl chloride
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test animals

Species:
other: rat, HanIbm:WIST (SPF)

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
other: Olivenöl

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
996 mg/kg bw
95% CL:
769 - 1 316
Remarks on result:
other: Slope of the mortality curve: 3.1
Mortality:
Male: 500 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 750 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 1
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 500 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 750 mg/kg bw; Number of animals: 5; Number of deaths: 3
Female: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Clinical signs:
Signs of toxicity related to dose levels:
Alle Sterbefälle geschahen in den ersten zwei
Beobachtungstagen. In allen Dosisgruppen wurde Sedation,
Kauerstellung, unkoordinierte Bewegungen und Dyspnoe
beobachtet.
"ENGLISH"
All of the mortalities occurred in the first two days of
observation. Sedation, squatting, uncoordinated movements
and dyspnoea were observed in all of the dose groups.
Gross pathology:
Effects on organs:
Bei den überlebenden Tieren wurde keine makroskopischen
Veränderungen beobachtet.
Bei den toten Tieren beobachtete man bei:
750 mg/kg: 2 von 3 Tieren hatten eine dunkelrot
verfärbte Lunge.
1000 mg/kg: 4 von 6 Tieren hatten eine dunkelrot
verfärbte Lunge.
2000 mg/kg: 2 von 9 Tieren hatten eine dunkelrot
verfärbte Lunge.
"ENGLISH"
No macroscopic changes were observed among the surviving
animals. The following observations were made in the case of
the deceased animals.
750 mg/kg: 2 out of 3 animals had a dark-red discoloured
lung.
1000 mg/kg: 4 out of 6 animals had a dark-red discoloured
lung.
2000 mg/kg: 2 out of 9 animals had a dark-red discoloured
lung.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU