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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well documented study published in Literature. No details on GLP and/or Guideline followed.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1984

Materials and methods

Test guideline
Guideline:
other: no data
Principles of method if other than guideline:
See publication for details
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-(6-methylbenzothiazol-2-yl)aniline
EC Number:
202-150-4
EC Name:
4-(6-methylbenzothiazol-2-yl)aniline
Cas Number:
92-36-4
Molecular formula:
C14H12N2S
IUPAC Name:
4-(6-methyl-1,3-benzothiazol-2-yl)aniline

Test animals

Species:
rat
Strain:
Crj: CD(SD)
Sex:
male

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
whole body
Vehicle:
air
Analytical verification of doses or concentrations:
yes
Duration of treatment / exposure:
10 days: 5 days followed by 2 rest days and 5 more exposure days.
Frequency of treatment:
6h/d
Doses / concentrations
Remarks:
Doses / Concentrations:
0.68 mg/l
Basis:
no data
No. of animals per sex per dose:
10
Control animals:
yes, sham-exposed
Details on study design:
given in publication

Results and discussion

Results of examinations

Clinical signs:
effects observed, treatment-related
Description (incidence and severity):
Changes in Liver weight, changes in spleen weight, Changes in erythrocyte (RBC count)
Mortality:
mortality observed, treatment-related
Description (incidence):
Changes in Liver weight, changes in spleen weight, Changes in erythrocyte (RBC count)
Body weight and weight changes:
effects observed, treatment-related
Description (incidence and severity):
Weight loss
Haematological findings:
effects observed, treatment-related
Description (incidence and severity):
increased serum enzyme activity, kidney turbular degeneration in one rat
Urinalysis findings:
effects observed, treatment-related
Description (incidence and severity):
excetion of large volumes of less concentrated urine
Organ weight findings including organ / body weight ratios:
effects observed, treatment-related
Description (incidence and severity):
increased liver weight
Gross pathological findings:
effects observed, treatment-related
Description (incidence and severity):
Liver changes

Effect levels

open allclose all
Dose descriptor:
other: TCLo
Effect level:
680 mg/kg bw/day (actual dose received)
Sex:
male
Dose descriptor:
conc. level: TCLo
Effect level:
0.68 mg/L air (analytical)
Sex:
male

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
The study was performed as a 10 days subchronic study. The results justify a classification as STOT RE 2.