Registration Dossier
Registration Dossier
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EC number: 939-291-2 | CAS number: 90583-10-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Reference Type:
- secondary source
- Title:
- SIDS Category of Alkyl sulfates, Alkane sulfonates and Alpha-olefin sulfonates
- Author:
- OECD
- Year:
- 2 007
- Bibliographic source:
- UNEP Publications
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- yes
- Remarks:
- Only limited data on test item and methodology available
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 142-31-4 (purity 31.7%)
- IUPAC Name:
- 142-31-4 (purity 31.7%)
- Details on test material:
- - Name of test material (cited in study report): No data
- Physical state: No data
- Analytical purity: 31.7% a.i.
- Lot/batch No.: No data
- Storage condition of test material: No data
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- other: water
- Concentration:
- 12.5 µl of a 10, 50 or 100% solution
- No. of animals per dose:
- 5
Results and discussion
In vivo (LLNA)
Results
- Parameter:
- SI
- Remarks on result:
- other: 1.25, 2.7 or 3.1
Any other information on results incl. tables
The treatment had no significant effect on thymidine incorporation by
auricular lymph node cells when compared with naive and carrier controls:
stimulation index: 1.25, 2.7 or 3.1
naive control: 2.4
carrier control: 1
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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