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EC number: 208-031-3 | CAS number: 506-30-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
The substance Eicosanoic acid is not expected to show acute toxicity effect by the oral, inhalation and dermal route.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Principles of method if other than guideline:
- The prediction is done using QSAR toolbox version 3.1
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- mouse
- Strain:
- other: NMRI
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5000 mg/kg bw - 9800 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 8 250 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Non toxic to mouse.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The lethal dose (LD50) of Eicosanoic acid in mouse was found to be 8250 mg/kg of body weight.Toxic effects was not observed. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that Eicosanoic acid does not exhibit acute toxicity via the oral route i.e it is acutely non toxic to animals within the dose level mentioned in the study.
- Executive summary:
The acute toxicity study was conducted to evaluate the toxic effects of administration of Eicosanoic acid to mouse by the oral route. The mouse were given the test substance by the oral route at a dose concentration of 5000 - 9800 mg/kg of Eicosanoic acid.The lethal dose (LD50) of Eicosanoic acid in mouse was found to be 8250 mg/kg of body weight.Toxic effects was not observed. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that Eicosanoic acid does not exhibit acute toxicity via the oral route i.e it is acutely non toxic to animals within the dose level mentioned in the study.
Reference
The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Takes average value from the 4 nearest neighbours
Domain logical expression:Result: In Domain
(((((("a" and ("b" and ( not "c") ) ) and ("d" and ( not "e") ) ) and ("f" and ( not "g") ) ) and "h" ) and "i" ) and ("j" and "k" ) )
Domain logical expression index: "a"
Similarity boundary:Target: C(=O)(O)CCCCCCCCCCCCCCCCCCC
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as No alert found by Protein binding by OASIS v1.1
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Acylation OR Acylation >> Direct acylation involving a leaving group OR Acylation >> Direct acylation involving a leaving group >> Acid anhydrides OR Acylation >> Ester aminolysis or thiolysis OR Acylation >> Ester aminolysis or thiolysis >> Activated alkyl or aryl esters OR Michael addition OR Michael addition >> Michael addition on conjugated systems with electron withdrawing group OR Michael addition >> Michael addition on conjugated systems with electron withdrawing group >> alpha,beta-carbonyl compounds with polarized double bonds OR Nucleophilic addition OR Nucleophilic addition >> Addition to Carbon-hetero double/triple bond OR Nucleophilic addition >> Addition to Carbon-hetero double/triple bond >> Ketones OR SN2 OR SN2 >> Nucleophilic substitution at sp3 Carbon atom OR SN2 >> Nucleophilic substitution at sp3 Carbon atom >> Activated alkyl esters OR SN2 >> Nucleophilic substitution at sp3 Carbon atom >> alpha-haloalkanes OR SN2 >> Nucleophilic substitution on benzylic carbon atom OR SN2 >> Nucleophilic substitution on benzylic carbon atom >> Benzylic esters OR SN2 >> Ring opening SN2 reaction OR SN2 >> Ring opening SN2 reaction >> Epoxides, Aziridines and Sulfuranes by Protein binding by OASIS v1.1
Domain logical expression index: "d"
Referential boundary: The target chemical should be classified as No alert found by Protein binding by OECD
Domain logical expression index: "e"
Referential boundary: The target chemical should be classified as Michael addition OR Michael addition >> Polarised Alkenes OR Michael addition >> Polarised Alkenes >> Polarised alkene - ketones by Protein binding by OECD
Domain logical expression index: "f"
Referential boundary: The target chemical should be classified as Group 14 - Carbon C AND Group 16 - Oxygen O by Chemical elements
Domain logical expression index: "g"
Referential boundary: The target chemical should be classified as Group 14 - Metals Sn,Pb OR Group 15 - Nitrogen N OR Group 15 - Phosphorus P OR Group 17 - Halogens Br OR Group 17 - Halogens Cl OR Group 17 - Halogens F OR Group 17 - Halogens F,Cl,Br,I,At by Chemical elements
Domain logical expression index: "h"
Referential boundary: The target chemical should be classified as Not bioavailable by Lipinski Rule Oasis
Domain logical expression index: "i"
Similarity boundary:Target: C(=O)(O)CCCCCCCCCCCCCCCCCCC
Threshold=60%,
Dice(Atom pairs)
Domain logical expression index: "j"
Parametric boundary:The target chemical should have a value of log Kow which is >= 8.11
Domain logical expression index: "k"
Parametric boundary:The target chemical should have a value of log Kow which is <= 11.4
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 8 250 mg/kg bw
- Quality of whole database:
- The data is K2 level as the data has been obtained from QSAR model considered by OECD.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Principles of method if other than guideline:
- The prediction is done using QSAR toolbox version 3.1
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 hours
- No. of animals per sex per dose:
- 5 males and females
- Control animals:
- not specified
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 3 575.76 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Effects not observed.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The lethal dose (LD50) of Eicosanoic acid in New Zealand White rabbit was found to be 3575.76 mg/kg of body weight.Toxic effects was not observed. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that Eicosanoic acid does not exhibit acute toxicity via the dermal route i.e it is acutely non toxic to animals within the dose level mentioned in the study.
- Executive summary:
The acute toxicity study was conducted to evaluate the toxic effects of administration of Eicosanoic acid to New Zealand White rabbit by the dermal route. The lethal dose (LD50) of Eicosanoic acid in rabbit was found to be 3575.76 mg/kg of body weight.Toxic effects was not observed. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that Eicosanoic acid does not exhibit acute toxicity via the dermal route i.e it is acutely non toxic to animals within the dose level mentioned in the study.
Reference
The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Takes average value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
(("a" and "b" ) and ("c" and "d" ) )
Domain logical expression index: "a"
Similarity boundary:Target: C(=O)(O)CCCCCCCCCCCCCCCCCCC
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Low (Class I) by Toxic hazard classification by Cramer (original)
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is >= 7
Domain logical expression index: "d"
Parametric boundary:The target chemical should have a value of log Kow which is <= 10.1
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 575.76 mg/kg bw
- Quality of whole database:
- The data is K2 level as the data has been obtained from QSAR model considered by OECD.
Additional information
Based on weight of evidence approach no. of studies were reviewed for acute oral toxicity with Klimish rating 2 and 4 for the target and the read across substance for CAS: 506-30-9.
The results are summarized as follows
Sr.No |
Endpoint |
Effect values |
Species |
Sources |
1. |
LD50 |
8250 mg/kg bw |
Mouse |
Predicted data for target CAS :506-30-9 |
2. |
LDL0 |
4640 mg/kg bw |
Rat |
Data from publication for RA CAS: 57-11-4 |
3. |
LD50 |
>2000 mg/kg bw |
Rat |
Data from study report for RA CAS :112-85-6 |
4. |
LD50 |
10000 mg/kg bw |
Rat |
Data from publication for RA CAS :57-10-3 |
Based on the studies summarized in the above table for target substance Eicosanoic acid and the read across substance,the endpoint value was found to vary between lethal dose (LD50) = >2000 mg/kg bw to 10000 mg/kg bw and the Lowest published lethal dose (LDLo) = 4640 mg/kg bw.Toxic effects was not observed. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that Eicosanoic acid does not exhibit acute toxicity via the oral route i.e it is acutely non toxic to animals within the dose level mentioned in the study.
Acute toxicity: inhalation
This data was considered for waiver considering the low vapour pressure of this chemical (0.0000446 Pa ) as well as the particle size distribution. Majority of the particles were found to be in the size 1000 (65.03%) micrometer in size which is much larger size range compared to the inhalable particulate matter. Thus, exposure to inhalable dust, mist and vapour of the chemical Eicosanoic acid is highly unlikely.
Acute toxicity: dermal
Based on weight of evidence approach no. of studies were reviewed for acute dermal toxicity with Klimish rating 2 and 4 for the target and the read across substance for CAS: 506-30-9.
The results are summarized as follows
Sr.No |
Endpoint |
Effect values |
Species |
Sources |
1. |
LD50 |
3575.76 mg/kg bw |
Rabbit |
Predicted data for target CAS :506-30-9 |
2. |
LD50 |
>5000 mg/kg bw |
Rabbit |
Experimental data for RA CAS: 57-11-4 |
Based on the studies summarized in the above table for target substance Eicosanoic acid and the read across substance,the endpoint value was found to vary between lethal dose (LD50) = 3575.76 mg/kg bw to >5000 mg/kg bw.Toxic effects was not observed. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that Eicosanoic acid does not exhibit acute toxicity via the dermal route i.e it is acutely non toxic to animals within the dose level mentioned in the study.
Justification for selection of acute toxicity – oral endpoint
The acute toxicity study was conducted to evaluate the toxic effects of administration of Eicosanoic acid to mouse by the oral route. The mouse were given the test substance by the oral route at a dose concentration of 5000 - 9800 mg/kg of Eicosanoic acid.The lethal dose (LD50) of Eicosanoic acid in mouse was found to be 8250 mg/kg of body weight.Toxic effects was not observed. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that Eicosanoic acid does not exhibit acute toxicity via the oral route i.e it is acutely non toxic to animals within the dose level mentioned in the study.
Justification for selection of acute toxicity – inhalation endpoint
This data was considered for waiver considering the low vapour pressure of this chemical (0.0000446 Pa ) as well as the particle size distribution. Majority of the particles were found to be in the size 1000 (65.03%) micrometer in size which is much larger size range compared to the inhalable particulate matter. Thus, exposure to inhalable dust, mist and vapour of the chemical Eicosanoic acid is highly unlikely.
Justification for selection of acute toxicity – dermal endpoint
The acute toxicity study was conducted to evaluate the toxic effects of administration of Eicosanoic acid to New Zealand White rabbit by the dermal route. The lethal dose (LD50) of Eicosanoic acid in rabbit was found to be 3575.76 mg/kg of body weight.Toxic effects was not observed. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that Eicosanoic acid does not exhibit acute toxicity via the dermal route i.e it is acutely non toxic to animals within the dose level mentioned in the study.
Justification for classification or non-classification
Based upon the study results and available information, the substance Eicosanoic acid is not expected to show acute toxicity effect by the oral, inhalation and dermal route and thus will not be considered for further classification.
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