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Toxicity to aquatic algae and cyanobacteria

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Description of key information

Bis(2-ethylhexyl) carbonate is non-toxic to aquatic algae. ErC50, EbC50 and NOEC (72 h) Desmodesmus subspicatus: > 21.4 µg/L (water solubility limit under test conditions of OECD guideline 201). The calculated chronic NOEC for aquatic green algae exceeds the water solubility limit of the substance by a factor of 19.5.

Key value for chemical safety assessment

Additional information

In a 72-hour toxicity study according to OECD guidelines 201 (Alga, Growth Inhibition Test) (1984), cultures of Desmodesmus subspicatus were exposed under static conditions to Bis(2-ethylhexyl) carbonate at initial mean measured concentrations of 21.4 µg/L (the saturation concentration under test conditions). The water solubility of the test substance according to the sponsor of the study is < 0.03 mg/L. Nominal loading was 30 µg/L. The test item did not cause any toxic effects to the algae. This study is classified as reliable without restriction and satisfies the guideline requirements for a toxicity study with algae.

ErC50, EbC50 and NOEC (72 h) Desmodesmus subspicatus: > 21.4 µg/L, the saturation concentration under test conditions.

Thus, up to its solubility limit under the test conditions of OECD guideline 201 Bis(2-ethylhexyl) carbonate is not acute toxic to aquatic algae.

This is supported by results obtained from a valid QSAR model:The chronic toxicity value of Bis(2-ethylhexyl) carbonate to green algae is estimated to be 0.584 mg/L, the 96 h EC50 is estimated to be 1.152 mg/L (ECOSAR v1.11).