α-hydroxy-β,β-dimethyl-γ-butyrolactone

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

18.09 - 24.09.2009

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: According to guideline, under GLP

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2009

Report date:

2009

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Principles of method if other than guideline:

Not relevant

GLP compliance:

yes (incl. QA statement)

Type of method:

gas saturation method

Test material

Test material information

Constituent 1

Reference substance name:

α-hydroxy-β,β-dimethyl-γ-butyrolactone

EC Number:

209-963-3

EC Name:

α-hydroxy-β,β-dimethyl-γ-butyrolactone

Cas Number:

599-04-2

Molecular formula:

C6H10O3

IUPAC Name:

(3R)-3-hydroxy-4,4-dimethyloxolan-2-one

Constituent 2

Reference substance name:

209 963 3

IUPAC Name:

209 963 3

Details on test material:

- Name of test material (as cited in study report): R-Pantolactone
- Physical state: solid
- Storage condition of test material: at RT (20°C)

Results and discussion

Vapour pressure

Vapour pressure 1

Temp.:

15 °C

Vapour pressure:

0.3 Pa

Remarks on result:

other: measured

Vapour pressure 2

Temp.:

25 °C

Vapour pressure:

1.1 Pa

Remarks on result:

other: measured

Vapour pressure 3

Temp.:

35 °C

Vapour pressure:

3.2 Pa

Remarks on result:

other: measured

Vapour pressure 4

Temp.:

25 °C

Vapour pressure:

1 Pa

Remarks on result:

other: interpolated

Any other information on results incl. tables

To ensure saturation control, three different flow rates were used at each temperature. Higher flow rates did not lead to lower vapor pressures, which means that the nitrogen was saturated with test item under the conditions of the test.

Applicant's summary and conclusion

Conclusions:

Calculation of the vapor pressure of R-Pantolactone at 25 °C by interpolation based upon the
simplified Clausius-Clapeyron equation resulted in a vapor pressure of
1.0 Pa at 25 °C.

Executive summary:

During this study, the vapor pressure of the test item R-Pantolactone has been determined using the gas saturation method. The vapor pressure of R-Pantolactone was measured at test temperatures of 15 °C, 25 °C and 35 °C and was determined to be 0.3 Pa at 15 °C, 1.1 Pa at 25 °C and 3.2 Pa at 35 °C. The vapor pressure of R-Pantolactone at 25 °C was interpolated from the vapor pressure curve and was calculated to be 1.0 Pa at 25 °C.