Registration Dossier
Registration Dossier
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EC number: 606-376-8 | CAS number: 197721-70-3
Vapour pressure
Administrative data
Link to relevant study record(s)
Description of key information
GLP study according to EU Method A.4 (Effusion method: Vapor pressure balance).
General Physical Chemistry, Schering AG, Berlin, Study report No. NJ18EY10 (APC96/99), dated 1999-11-10
Key value for chemical safety assessment
Additional information
The temperature dependence of the vapor pressure of Hydroxydrospirenone was determined with the Knudsen effusion method using a vapor pressure balance in the temperature range 128-163 °C.
The following vapor pressures (with 95% confidence limits) were calculated for 20°C, 25°C and 30 °C using a semilogarithmic linear regression based on the Antoin equation to be:
P20= 7.0 · 10-10Pa (1.2 · 10-10– 4.0 · 10-9Pa)
P25= 1.7 · 10-9Pa (3.2 · 10-10– 8.9 · 10-9Pa)
P30= 4.0 · 10-9Pa (8.3 · 10-10– 1.9 · 10-8Pa)
The Henry constant was estimated to be:
H = 1.1 · 10-12
Thus Hydroxidrospirenone is to be considered nonvolatile in aqueous solution.
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