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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to Guideline study (non-GLP).

Data source

Reference
Reference Type:
publication
Title:
The comparative acute toxicity and primary irritancy of the monohexyl ethers of ethylene and diethylene glycol.
Author:
Ballantyne, B. & Myers, R.C.
Year:
1987
Bibliographic source:
Vet. Hum. Toxicol. 29, 361-366

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2-hexyloxyethoxy)ethanol
EC Number:
203-988-3
EC Name:
2-(2-hexyloxyethoxy)ethanol
Cas Number:
112-59-4
Molecular formula:
C10H22O3
IUPAC Name:
2-[2-(hexyloxy)ethoxy]ethanol
Details on test material:
- Name of test material (as cited in study report): diethylene glycol monohexyl ether
- Ethoxylation degree: 2
- Physical state: Colourless liquid
- Analytical purity: No data
- Lot/batch No.: No data
- Storage condition of test material: No data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
As described in guideline.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
males: 0.9, 1.9, 3.7, 7.4, 15.0 g/kg bw
females: 1.9, 3.7, 7.4 g/kg bw
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
4 600 mg/kg bw
Sex:
female
Dose descriptor:
LD50
Effect level:
3 488 mg/kg bw
Mortality:
Mortalities occurred at a dose level of 3.7 g/kg bw and above.
Clinical signs:
Signs of toxicity included sluggishness, unsteady gait and a prostrated appearance at all doses.
Body weight:
No treatment-related effects.
Gross pathology:
Animals that died showed dark red or dark pink lungs.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU