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EC number: 700-308-1 | CAS number: 1335203-19-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1989-01-24 to 1989-02-07
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to or similar to guideline study OECD 402 or Directive 92/69/EEC Method B3: GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 151006-58-5
- EC Number:
- 604-766-2
- Cas Number:
- 151006-58-5
- IUPAC Name:
- 151006-58-5
- Reference substance name:
- 1-DODECENE, DIMER WITH 1-DECENE
- IUPAC Name:
- 1-DODECENE, DIMER WITH 1-DECENE
- Reference substance name:
- -
- EC Number:
- 417-050-8
- EC Name:
- -
- Molecular formula:
- C22H46
- IUPAC Name:
- Hydrogenated dimerization products of 1-dodecene and 1-decene
- Reference substance name:
- REACTION PRODUCTS OF 1-DECENE AND 1-DODECENE, DIMER, HYDROGENATED
- IUPAC Name:
- REACTION PRODUCTS OF 1-DECENE AND 1-DODECENE, DIMER, HYDROGENATED
- Details on test material:
- - Name of test material (as cited in study report): Oronite XS 101 (KWA 88-01217)
- Physical state: colorless liquid
- Storage condition of test material: room temperature
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Bantin Kingman inc.
- Age at study initiation: 10 weeks (males); 11 weeks (females)
- Weight at study initiation: 296-361 g (males); 212-240 g (females)
- Fasting period before study: None
- Housing: individually
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 4 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-23
- Humidity (%): 30-50
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: trunk
- Type of wrap if used: Test material was held in contact with the animals skin by plastic film wrapped around the trunk, and Peg Wrap was placed over the plastic to prevent tearing.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): after exposure period, excess was wiped off with gauze
- Time after start of exposure: 24h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.650g (+/- 0.047) for males; 0.445 (+/- 0.021) for females
- Constant volume or concentration used: yes
- Duration of exposure:
- 24-hour exposure period
- Doses:
- 2.0g/kg
- No. of animals per sex per dose:
- Five untreated animals of each sex; five treated (2.0g/kg) animals of each sex
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observed frequently on day of dosing and twice daily thereafter except weekends and holidays when animals were observed once a day. Animals were weighed immediately before dosing and on Days 2, 7, and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology, other: pupil response was examined before dosing and on Days 1, 7, and 14.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: No signs of toxicity were seen. Skin irritation was observed in both control and treated animals; however irritation was more severe and persistent in treated animals with cracking and scarring also being observed.
- Gross pathology:
- A dilated pelvis was observed at necropsy in the kidney of one male from the 2.0g/kg dose group. It has been determined from previous studies that this is a common finding in Sprague-Dawley Rats and not treatment-related.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 for Oronite XS 101 is greater than 2000 mg/kg. This finding does not warrant classification of Oronite XS 101 as an acute dermal toxicant under EU GHS guidelines and does not warrant classification under EU requirements for dangerous substances and preparations.
- Executive summary:
Oronite XS 101 was applied to the clipped backs of ten Sprague-Dawley rats for 24 hours at a dose of 2000mg/kg under occlusive binding to assess the acute dermal toxicity. Five clipped, untreated animals of each sex were similarly wrapped and served as sham controls. The animals were observed frequently on the day of dosing for any physiological or behavioral abnormalities and daily thereafter. No deaths or signs of systemic toxicity were observed. Skin irritation including erythema, cracking and scarring was seen in both control and treated animals; however, irritation was more severe and persistent in treated animals than in controls. The dermal LD50 for Oronite XS 101 is greater than 2000 mg/kg. This finding does not warrant the classification of Oronite XS 101 as an acute dermal toxicant under EU GHS guidelines and does not warrant classification under EU requirements for dangerous substances and preparations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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