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EC number: 700-308-1 | CAS number: 1335203-19-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to or similar to study guidelines OECD 471: GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Version / remarks:
- and Method B14 (92/69/EEC Directive)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Dec-1-ene, dimers, hydrogenated
- EC Number:
- 500-228-5
- EC Name:
- Dec-1-ene, dimers, hydrogenated
- Cas Number:
- 68649-11-6
- Molecular formula:
- C20H42
- IUPAC Name:
- Hydrogenated dimerization products of 1-decene
- Reference substance name:
- 1-decene dimer, hydrogenated
- IUPAC Name:
- 1-decene dimer, hydrogenated
- Details on test material:
- - Name of test material (as cited in study report):MCP992
- Physical state: amber liquid
- Storage condition of test material: room temperature
Constituent 1
Constituent 2
Method
- Target gene:
- Not applicable
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 liver microsomal fraction from Arochlor 1254 induced male SD rats
- Test concentrations with justification for top dose:
- 10ul/50ul, 3.1ul/50ul, 0.97/50ul, 0.3ul/50ul, and 0.094ul/50ul
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: acetone
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
- Remarks:
- Vehicle is acetone
Migrated to IUCLID6: 2-aminoanthracene, 2-nitrofluorene, N-methyl-N-nitro-N-nitrosoguanidine
- Details on test system and experimental conditions:
- Serial dilutions were prepared in acetone to deliver 10, 3.1, 0.97, 0.3, and 0.094ul of test material in plates with and without metabolic activation in 50ul aliquots per bacterial plate. Five concentrations of the test material were assayed in triplicate against each tester strain, using the direct plate incorporation method. Measured aliquots of one of the bacterial cultures were dispensed into sets of test tubes followed by 2.0ml of molten, trace histidine supplemented , top agar, 0.1ml of the test material formulation, vehicle or positive control and either 0.5ml S9-mix or phosphate buffer. The contents of each test tube were mixed and equally distributed onto the surface of agar plates. This procedure was repeated, in triplicate, for each bacterial strain and for each concentration of test material both with and without S9-mix.
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity nor precipitates, but tested up to recommended limit concentrations
- Remarks:
- No toxicity at 5000 ug/plate
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
The bacterial reverse mutation test to assess the genotoxicity of the test material was negative. This finding does not warrant classification of the test material as a mutagen under the new Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations. - Executive summary:
The test material was studied in the Ames assay using Salmonella typhimurium test strains TA98, TA100, TA102, TA1535, and TA1537 in the absence and presence of a liver S9 fraction for metabolic activation. Two tests were performed using five dose levels. The test material did not induce any significant changes in the number of revertant colonies with or without metabolic activation and was not cytotoxic and any dose level. All of the positive control chemicals used in the test induced marked increases in the frequency of revertant colonies. It is concluded that in this study, the test material is not a mutagenic agent. This finding does not warrant classification of the test material as a genotoxin under the new Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
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