Registration Dossier
Registration Dossier
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EC number: 422-310-9 | CAS number: 114772-53-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Methode de Draize, JO du 21 avril 1971, modifie le 1 fevrier 1982
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 422-310-9
- EC Name:
- -
- Cas Number:
- 114772-53-1
- Molecular formula:
- C14H11N
- IUPAC Name:
- 4'-methyl-[1,1'-biphenyl]-2-carbonitrile
Constituent 1
Test animals
- Species:
- other: Lapin New Zealand
Test system
- Type of coverage:
- occlusive
- Vehicle:
- other: Gaze humididiee avec 0.5 ml d'eau
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 24h
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: Overall at 24, 48 and 72h
- Score:
- 0
- Reversibility:
- fully reversible within: 1d
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: Overall at 24, 48 and 72h
- Score:
- 0.33
- Reversibility:
- fully reversible within: 1d
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: Overall at 24, 48 and 72h
- Score:
- 0
- Reversibility:
- fully reversible within: 1d
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: Overall at 24, 48 and 72h
- Score:
- 0
- Reversibility:
- fully reversible within: 1d
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: Overall at 24, 48 and 72h
- Score:
- 0
- Reversibility:
- fully reversible within: 1d
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: Overall at 24, 48 and 72h
- Score:
- 0
- Reversibility:
- fully reversible within: 1d
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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