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Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1996

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Methode de Draize, JO du 21 avril 1971, modifie le 1 fevrier 1982
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
422-310-9
EC Name:
-
Cas Number:
114772-53-1
Molecular formula:
C14H11N
IUPAC Name:
4'-methyl-[1,1'-biphenyl]-2-carbonitrile

Test animals

Species:
other: Lapin New Zealand

Test system

Type of coverage:
occlusive
Vehicle:
other: Gaze humididiee avec 0.5 ml d'eau
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
24h
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: Overall at 24, 48 and 72h
Score:
0
Reversibility:
fully reversible within: 1d
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: Overall at 24, 48 and 72h
Score:
0.33
Reversibility:
fully reversible within: 1d
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: Overall at 24, 48 and 72h
Score:
0
Reversibility:
fully reversible within: 1d
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: Overall at 24, 48 and 72h
Score:
0
Reversibility:
fully reversible within: 1d
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: Overall at 24, 48 and 72h
Score:
0
Reversibility:
fully reversible within: 1d
Irritation parameter:
edema score
Basis:
animal #3
Time point:
other: Overall at 24, 48 and 72h
Score:
0
Reversibility:
fully reversible within: 1d

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU

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