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Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study conducted in accordance with GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005
Report date:
2005

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Retinyl propionate
EC Number:
230-363-2
EC Name:
Retinyl propionate
Cas Number:
7069-42-3
Molecular formula:
C23H34O2
IUPAC Name:
retinyl propionate
Details on test material:
- Vitamin A-propionat, (retinyl-propionate)
- Purity: 95.9 w -%
- Batch No.: 00000777LO PBG-Nr.10540158
- Water solubility: < 10 ug/L at 20.0 °C ± 0.1 °C

Sampling and analysis

Analytical monitoring:
no

Test organisms

Test organisms (species):
activated sludge, domestic
Details on inoculum:
- Laboratory culture: activated sludge obtained from a laboratory wastewater plant treating municipal sewage
- Initial biomass concentration: 1 g/L dry matter

Study design

Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
180 min

Test conditions

Test temperature:
20 ± 2 °C
Details on test conditions:
TEST SYSTEM
- Test vessel:
- Material, total volume, test volume: Erlenmeyer-vessel, 250 ml, 250 ml
- Synthetic medium: 8 ml/vessel 100-fold concentrated OECD medium
- Oxygen concentration during aeration: > 2.5 mg/l
- Oxygen concentration immediately before measurement: > 6.5 mg/l
- Duration of the measurement of oxygen consumption: 8 - 10 min


Reference substance (positive control):
yes
Remarks:
3,5-Dichlorophenol (500 mg/L)

Results and discussion

Effect concentrationsopen allclose all
Duration:
180 min
Dose descriptor:
other: EC20
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Duration:
180 min
Dose descriptor:
EC50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Duration:
180 min
Dose descriptor:
other: EC80
Effect conc.:
> 1 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Results with reference substance (positive control):
Effect concentrations after 180 min (nominal):
EC20 = ca. 1.2 mg/L
EC50 = ca. 18 mg/L
EC80 = ca. 50 mg/L

Applicant's summary and conclusion

Validity criteria fulfilled:
yes