Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 230-363-2 | CAS number: 7069-42-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
A reliable skin and eye irritation GLP guideline (OECD 404, 405) study was performed in the rabbit. In the skin irritation study, a mean score of >=2.0 (but <2.3 in 2/3 animals) for erythema (24, 48 and 72 hours) and desquamation or scabbing, epidermal lesions and scaling was observed in 3/3 animals. For eye irritation, the mean irritation score for conjuctival redness was 0.33 (at both 24 and 48 hr based on one animal only).
Key value for chemical safety assessment
Additional information
The key study for skin irritation was performed according to GLP and OECD guideline 404, using New Zealand White Rabbits and retinyl propionate (purity approx. 90%; DSM B-154'448).
Reversible erythema and edema was observed. Individual erythema mean scores(24 -72 hrs) were >=2 (but <2.3 in 2/3 animals) and reversible desquamation or scabbing, epidermal lesions and scaling was observed in 3/3 animals. Therefore retinyl propionate was identified to be irritating to the skin.
The key study for eye irritation was performed according to GLP and OECD guideline 405, using New Zealand White Rabbits and retinol propionate (approx. 90%; DSM B-154'433). Slight conjuctival redness was observed in 1/3 animals (reversible after 72 hours)
. No effects on corneal opacity, iris lesion or chemosis of the conjuctivae were noted. The test substance was not an eye irritant under the conditions of the study.Effect level: empty Endpoint conclusion: Adverse effect observed
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Skin irritation:
The present data fulfill the criteria laid down in 67/548/EEC and a classification "irritating to skin" (R38) is warranted.
According to 1272/2008/EEC, a non-classification is warranted. According to UN-GHS, the test substance needs to be classified "skin irritant" (category 3).
Eye irritation:
The present data on eye irritation do not fulfill the criteria laid down in 67/548/EEC and 1272/2008/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.