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EC number: 272-238-5 | CAS number: 68784-31-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: This study was designed to test adverse effects of the thermal degredation products of the test material but not the material itself. No LC50 determined.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Phosphorodithioic acid, mixed O,O-bis(sec-Bu and 1,3-dimethylbutyl) esters, zinc salts
- EC Number:
- 272-238-5
- EC Name:
- Phosphorodithioic acid, mixed O,O-bis(sec-Bu and 1,3-dimethylbutyl) esters, zinc salts
- Cas Number:
- 68784-31-6
- Molecular formula:
- C(16-24) H(36-42) O4 P2 S4 Zn
- IUPAC Name:
- Phosphorodithioic acid, mixed O,O-bis(sec-Bu and 1,3-dimethylbutyl) esters, zinc salts
- Details on test material:
- Thermal decomposition of test material containing an average of:
- 102 ppm hydrogen sulfide
- 56 ppm 2-butanethiol
- 7 ppm 4-methyl-2-pentanethiol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:
- Age at study initiation: 80 days
- Weight at study initiation: 373-411 g (males); 250-283 (females)
- Fasting period before study:
- Housing: Individually
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 35 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22-24
- Humidity (%): 33-62
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 12 hours
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Hazleton 27 in cubical chambers with pyramidal tops and bottoms
- Exposure chamber volume:
- Method of holding animals in test chamber:
- Source and rate of air:
- Method of conditioning air:
- System of generating particulates/aerosols:
- Method of particle size determination:
- Treatment of exhaust air:
- Temperature, humidity, pressure in air chamber:
TEST ATMOSPHERE
- Brief description of analytical method used:
- Samples taken from breathing zone: yes/no
VEHICLE
- Composition of vehicle (if applicable):
- Concentration of test material in vehicle (if applicable):
- Justification of choice of vehicle:
- Lot/batch no. (if required):
- Purity:
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution:
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.):
CLASS METHOD (if applicable)
- Rationale for the selection of the starting concentration: - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 240 min
- Concentrations:
- 102 ppm hydrogen sulfide
56 ppm 2-butanethiol
7 ppm 4-methyl-2-pentanethiol - No. of animals per sex per dose:
- 8 male and 8 female
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days (or other?)
- Frequency of observations and weighing: 2, 7, and 11 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, gross pathology
Results and discussion
- Mortality:
- None
- Clinical signs:
- other: Squinted or closed eyes. Labored breathing in two males.
- Body weight:
- No change betweent exposed and control
- Gross pathology:
- No gross pathologic changes were attributed to the exposure.
Any other information on results incl. tables
No mortality was observed during the study. During the exposure, squinted or closed eyes were observed in all exposed animals and two exposed males showed slightly labored breathing near the end of the exposure. There were no signs of toxicity observed in exposed animlas following the exposure or in control animlas throughout the study. There were no significant differences in mean body weights between exposed and control animals for either sex, 2, 7, or 11 days following the exposure.
No gross pathologic changes that could be attributed to the exposure were observed at necropsy following an 11 -day expsoure period.
Applicant's summary and conclusion
- Interpretation of results:
- other: Study did not evaluate substance being registered but rather thermal degradation products of substance being registered. No lethal dose or benchmark dose was established.
- Remarks:
- Criteria used for interpretation of results: other: This study cannot be used for classification purposes
- Conclusions:
- The actue toxicity of the degredation prodcuts of the test material does not appear to be substantially greater than hydrogen sulfide.
- Executive summary:
The intent of the study was to measure the thermal decomposition products from phosphorodithioc acid, mixed O,O-bis(sec-butyl and 1,3 -dimethylbutyl) esters, zinc salts. Degradation results in formation of hydrogen sulfide and other gaseous products that may be of toxicological significance. The concentration of hydrogen sulfide was held at or around 100 ppm, below the minimum lethal concentration, to examine whether any unexcpected toxicity or lethality would occur from other materials.
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