Registration Dossier
Registration Dossier
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EC number: 293-261-7 | CAS number: 91052-99-2 A complex combination of hydrocarbons obtained from distillation of the butadiene-free C4 fraction of a naphtha steam-cracking process. It consists predominantly of branched olefinic hydrocarbons having carbon numbers of C8, C12, C16 and C20 and boiling in the range of approximately 105°C to 120°C (221°F to 248°F).
Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: long-term
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- See Attached Justification
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- - Software tool(s) used including version:
See Field 'Attached justification'
- Model(s) used:
See Field 'Attached justification'
- Model description: See Field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification' - GLP compliance:
- not specified
- Specific details on test material used for the study:
- HC Block Type Carbon Number % weight
i-Olefin 12 100
Total 100 - Test organisms (species):
- Lumbriculus variegatus
- Duration:
- 28 d
- Dose descriptor:
- other: LL50
- Effect conc.:
- 5 970 mg/kg sediment dw
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR prediction
- Basis for effect:
- mortality
- Remarks on result:
- other: QSAR predicted value
- Duration:
- 28 d
- Dose descriptor:
- other: EL10
- Effect conc.:
- 1 144 mg/kg sediment dw
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR prediction
- Basis for effect:
- other: biomass
- Remarks:
- reproduction
- Remarks on result:
- other: QSAR predicted value
- Validity criteria fulfilled:
- yes
- Conclusions:
- The QSAR predicted LL50 and EL10 for the UVCB substance were 5970 and 1144 mg/kg sediment dw respectively.
- Executive summary:
The QSAR predicted LL50 and EL10 for the UVCB substance for Lumbriculus variegatus were 5970 and 1144 mg/kg sediment dw, respectively. The model used for the calculations was the PETROTOX v4.0 model. PETROTOX is a well-documented and peer reviewed model that is widely used across the chemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.
- Endpoint:
- sediment toxicity: long-term
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- See Attached Justification
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- - Software tool(s) used including version:
See Field 'Attached justification'
- Model(s) used:
See Field 'Attached justification'
- Model description: See Field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification' - GLP compliance:
- not specified
- Specific details on test material used for the study:
- HC Block Type Carbon Number % weight
i-Olefin 16 100
Total 100 - Test organisms (species):
- Lumbriculus variegatus
- Duration:
- 28 d
- Dose descriptor:
- other: LL50
- Effect conc.:
- 1 294 570 mg/kg sediment dw
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR prediction
- Basis for effect:
- mortality
- Remarks on result:
- other: QSAR predicted value
- Duration:
- 28 d
- Dose descriptor:
- other: EL10
- Effect conc.:
- 248 002 mg/kg sediment dw
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR prediction
- Basis for effect:
- other: biomass
- Remarks:
- reproduction
- Remarks on result:
- other: QSAR predicted value
- Validity criteria fulfilled:
- yes
- Conclusions:
- The QSAR predicted LL50 and EL10 for the UVCB substance were 1294570 and 248002 mg/kg sediment dw respectively.
- Executive summary:
The QSAR predicted LL50 and EL10 for the UVCB substance for Lumbriculus variegatus were 1294570 and 248002 mg/kg sediment dw, respectively. The model used for the calculations was the PETROTOX v4.0 model. PETROTOX is a well-documented and peer reviewed model that is widely used across the chemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.
- Endpoint:
- sediment toxicity: long-term
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- See Attached Justification
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- - Software tool(s) used including version:
See Field 'Attached justification'
- Model(s) used:
See Field 'Attached justification'
- Model description: See Field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification' - GLP compliance:
- not specified
- Specific details on test material used for the study:
- HC Block Type Carbon Number % weight
i-Olefin 20 100
Total 100 - Test organisms (species):
- Lumbriculus variegatus
- Duration:
- 28 d
- Dose descriptor:
- other: LL50
- Effect conc.:
- 1 294 570 mg/kg sediment dw
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR prediction
- Basis for effect:
- mortality
- Remarks on result:
- other: QSAR predicted value
- Duration:
- 28 d
- Dose descriptor:
- other: EL10
- Effect conc.:
- 248 002 mg/kg sediment dw
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR prediction
- Basis for effect:
- other: biomass
- Remarks:
- reproduction
- Remarks on result:
- other: QSAR predicted value
- Validity criteria fulfilled:
- yes
- Conclusions:
- The QSAR predicted LL50 and EL10 for the UVCB substance were 1294570 and 248002 mg/kg sediment dw respectively.
- Executive summary:
The QSAR predicted LL50 and EL10 for the UVCB substance for Lumbriculus variegatus were 1294570 and 248002 mg/kg sediment dw, respectively. The model used for the calculations was the PETROTOX v4.0 model. PETROTOX is a well-documented and peer reviewed model that is widely used across the chemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.
- Endpoint:
- sediment toxicity: long-term
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- See Attached Justification
- Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- - Software tool(s) used including version:
See Field 'Attached justification'
- Model(s) used:
See Field 'Attached justification'
- Model description: See Field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification' - GLP compliance:
- not specified
- Specific details on test material used for the study:
- HC Block Type Carbon Number % weight
i-Olefin 8 100
Total 100 - Test organisms (species):
- Lumbriculus variegatus
- Duration:
- 28 d
- Dose descriptor:
- other: LL50
- Effect conc.:
- 221 mg/kg sediment dw
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR prediction
- Basis for effect:
- mortality
- Remarks on result:
- other: QSAR predicted value
- Duration:
- 28 d
- Dose descriptor:
- other: EL10
- Effect conc.:
- 42.3 mg/kg sediment dw
- Nominal / measured:
- estimated
- Conc. based on:
- other: QSAR prediction
- Basis for effect:
- other: biomass
- Remarks:
- reproduction
- Remarks on result:
- other: QSAR predicted value
- Validity criteria fulfilled:
- yes
- Conclusions:
- The QSAR predicted LL50 and EL10 for the UVCB substance were 221 and 42.3 mg/kg sediment dw respectively.
- Executive summary:
The QSAR predicted LL50 and EL10 for the UVCB substance for Lumbriculus variegatus were 221 and 42.3 mg/kg sediment dw, respectively. The model used for the calculations was the PETROTOX v4.0 model. PETROTOX is a well-documented and peer reviewed model that is widely used across the chemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.
Referenceopen allclose all
Description of key information
The sediment toxicity was predicted by a QSAR, the PETROTOX v4.0 computer model. PETROTOX is a well-documented and peer reviewed model that is widely used across the chemicals industry. The predicted LL50 values for Lumbriculus variegatus ranged from 221 to 1294570 mg/kg sediment dw. The predicted EL10 values for Lumbriculus variegatus ranged from 42.3 to 248002 mg/kg sediment dw.
Key value for chemical safety assessment
Additional information
| Species | Carbon No. | LL50 / EL50 (mg/kg_dw) | EL10 (mg/kg_dw) |
| Lumbriculus variegatus | C8 | 221 | 42.3 |
| Lumbriculus variegatus | C12 | 5970 | 1144 |
| Lumbriculus variegatus | C16 | 1294570 | 248002 |
| Lumbriculus variegatus | C20 | 1294570 | 248002 |
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
