Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

Skin sensitisation to TTP was determined in a guideline study (OECD TG 429, EU method B.42). TTP is a sensitiser. The submission substance is a Nickel complex with TTP as its ligand, which is expected to be rapidly released. Therefore NiL4 is found to be a sensitiser as well.

Migrated from Short description of key information:
Based on results for the surrogate substance, TTP, the submission substance is considered to be a sensitiser.

Respiratory sensitisation

Endpoint conclusion
Additional information:
Migrated from Short description of key information:
No information available

Justification for classification or non-classification

Based on the positive results of a skin sensitisation study of the surrogate substance TTP,

according to Regulation 1272/2008, the submission substance should be classified as skin sensitizer (Category 1) and labeled with H317: May cause an allergic skin reaction.

Based on an observed EC3 < 2% (SI at lowest tested concentration of 2.5% was 4.8) the substance is considered to be a strong sensitiser and a specific concentration limit of 0.1% (w/v) is set.