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In accordance with column 2 of REACH Annex IX, the bioaccumulation in aquatic species study does not need to be conducted as direct or indirect exposure of the aquatic compartment does not occur.

Further according to REACH Annex IX, 9.3.2, column 2 the bioaccumulation study does not need to be conducted if the substance has a low potential for bioaccumulation. Due to the high reactivity of the isocyanates with water, bioaccumulation tests can in principle not be performed with these substances. Rapid hydrolysis of the substance (and isocyanates in general) makes approximation of equilibrium in the environment impossible resulting in a low potential for bioaccumulation.

The hydrolysis products are mainly insoluble, inert oligomeric and polymeric ureas and thus not bioavailable. Theoretically the corresponding amine can be regarded which however is not formed in significant concentrations.