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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
other information
Study period:
July 1997
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: According to OECD guideline under GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997
Report date:
1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Deviations:
no
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
7 beta-Hydroxy-3 beta,15 alpha-dipivaloyloxy-5-androsten-17-one
EC Number:
617-708-6
Cas Number:
85390-94-9
Molecular formula:
C29 H44 O6
IUPAC Name:
7 beta-Hydroxy-3 beta,15 alpha-dipivaloyloxy-5-androsten-17-one
Details on test material:
- Name of test material (as cited in study report): Dipivalat (ZK 92136)
- Lot/batch No.: 21604815

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
48 h

Results and discussion

Effect concentrations
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 1 mg/L
Nominal / measured:
meas. (arithm. mean)
Conc. based on:
test mat.
Basis for effect:
mobility

Any other information on results incl. tables

Cumulative immobilization (%) of Daphnia magna (n=20) after exposure to ZK 92136

 Concentration of ZK 92136    24 hours    48 hours  
 0 mg/L control (tap water)   0 0
 Saturated solution   0 0

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The EC50/48 hours of ZK 92136 to Daphnia magna is higher than a saturated solution <1 mg/L).
Executive summary:

The purpose of this study was to determine the acute toxicity (immobilization, EC50/48 hours) of ZK 92136 with Daphnia magna in order to evaluate the aquatic toxicity. The study was conducted as a limit test in agreement with the guideline of the OECD, no. 202.

20 juvenile Daphnia magna were used for the test solution of ZK 92136 and 20 for the tap water contral. The Daphnia were exposed for a period of 48 hours under static conditions. As test solution, a suspension of 100 mg/L (saturated solution) was made. The organic carbon concentration of the test solution was analysed with a TOC analyser. The concentration was below the detection limit <1 mg/L).

No immobilized Daphnia was observed in the test solution.

The EC50/48 hours of ZK 92136 to Daphnia magna is higher than a saturated solution (<1mg/L).

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