Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-881-8 | CAS number: 14044-65-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant guideline study, available as unpublished report, no restrictions, fully adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Experimental Toxicology and Ecology, BASF Aktiengesellschaft, 67056 Ludwigshafen/Rhein, Germany
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Tetrahydrofuran-borane
- EC Number:
- 237-881-8
- EC Name:
- Tetrahydrofuran-borane
- Cas Number:
- 14044-65-6
- Molecular formula:
- C4H11BO
- IUPAC Name:
- Borane-tetrahydrofuran (1:1)
- Details on test material:
- - Name of test material (as cited in study report): Borane-tetrahydrofuran complex in tetrahydrofuran 1M
- Physical state: Liquid
- Analytical purity: The test substance was characterized analytically.
- Lot/batch No.: 101202346 resp. 101202350
- Storage condition of test material: Refrigerator, exclusion of air (covered with N2 )
- Homogeneity: The test substance was homogeneous by visual inspection
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: RCC Ltd Laboratory Animal Services, Wölferstrasse 4, CH-4414 Füllinsdorf, Switzerland
- Age at study initiation: approx. 8-12 weeks)
- Weight at study initiation: 176-189
- Fasting period before study: At least 16 hours before administration (water available ad libitum)
- Housing: Single housing in stainless steel wire mesh cages, type DK-III (Becker & Co., Castrop-Rauxel, FRG)
- Diet: Kliba-Labordiät (Maus / Ratte Haltung "GLP"), Provimi Kliba SA, Kaiseraugst, Basel, Switzerland, ad libitum
- Water: Tap water ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24
- Humidity (%): 30 - 70
- Photoperiod (hrs dark / hrs light): 12h/12h (6.00 a.m.-6.00 p.m./6.00 p.m.-6.00 a.m)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- - Time of day of administration: In the morning
- Amounts administered: 300 mg/kg: 0.34 mL/kg, 500 mg/kg: 0.57 mL/kg, 2000 mg/kg: 2.27 mL/kg,
CLASS METHOD
- Rationale for the selection of the starting dose: Based on the physical and chemical characteristics of the test substance and its composition a starting dose of 300 mg/kg body weight has been chosen in the first step with 3 female animals. Because all animals survived, 2,000 mg/kg body weight were administered to 3 female animals in a second step. As all animals died at the second step, 500 mg/kg body weight were administered to 3 female animals in a third step. Because no animals died at the third step, 500 mg/kg body weight have been tested in a fourth step with another group of 3 female animals. Because all animals survived the fourth step the study was terminated. - Doses:
- 300, 500, 2000 mg/kg
- No. of animals per sex per dose:
- 3 animals at 2000 and 300 mg/kg, 6 animals at 500 mg/kg.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: At least 14 days
- Body weight determination: Individual body weights shortly before administration (day 0), weekly thereafter and at the end of the study . Additionally, at day of death in animals that died or were sacrificed moribund starting with study day 1.
- Signs and symptoms: Several times on the day of administration, at least once each workday for the individual animals
- Mortality: A check for any dead or moribund animal was made twice each workday and once on Saturdays, Sundays and on public holidays.
- Pathology: Necropsy with gross-pathology examination on the last day of the observation period after killing by CO2-inhalation. Necropsy of all animals that died before as early as possible after death.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 500 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals of the 2,000 mg/kg administration group were found dead on study days 1 and 2. No mortality occurred in the 500 and 300 mg/kg administration groups.
- Clinical signs:
- other: Clinical observation in the 2,000 mg/kg administration group revealed poor general state, dyspnoea, abdominal and lateral position, piloerection, salivation and lacrimation and were observed from hour 0 until including study day 1 after administration. C
- Gross pathology:
- The following macroscopic pathologic findings were observed in the animals that died (2,000 mg/kg (3 females)): red discoloration of the glandular stomach (2 females), few brown erosions/ulcers in the glandular stomach, diameter up to 20 mm (1 female) and discoloration of contents of the small intestine (3 females). No macroscopic pathologic abnormalities were noted in the animals examined at termination of the study (500 mg/kg: 6 females; 300 mg/kg: 3 females).
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.