Registration Dossier
Registration Dossier
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EC number: 237-881-8 | CAS number: 14044-65-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in mammalian cells
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only a one page summary of the results is available, no details on experimental set-up given; no information about positive and negative controls
Data source
Reference
- Reference Type:
- secondary source
- Title:
- BORANE-TETRAHYDROFURAN COMPLEX
- Bibliographic source:
- National Institutes of Health, CCRIS data base
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Type of assay:
- mammalian cell gene mutation assay
Test material
- Reference substance name:
- Tetrahydrofuran-borane
- EC Number:
- 237-881-8
- EC Name:
- Tetrahydrofuran-borane
- Cas Number:
- 14044-65-6
- Molecular formula:
- C4H11BO
- IUPAC Name:
- Borane-tetrahydrofuran (1:1)
Constituent 1
Method
- Test concentrations with justification for top dose:
- 7.3-15 mL/mL
- Vehicle / solvent:
- Vehicle: ethanol
- Details on test system and experimental conditions:
- L5178Y (TK+/TK-) were used and incubated with the test substance with and withou metabolic activation (S9)
Results and discussion
Test results
- Species / strain:
- mouse lymphoma L5178Y cells
- Metabolic activation:
- with and without
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
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