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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Link to relevant study record(s)

Description of key information

48h EC50 (Daphnia magna, mobility) = 4.7 mg/L (nominal concentration, read-across, EG Guideline 92/69/EWG)
48h LC50 (Acartia tonsa, mortality) = 21 mg/L (nominal concentration, ISO 14669 (1999), ISO 5667-16 (1998))

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
4.7 mg/L

Marine water invertebrates

Marine water invertebrates
Effect concentration:
21 mg/L

Additional information

Two short-term toxicity studies with aquatic invertebrates are available for C12-14AS MEA (CAS 90583-16-7).

The key study was performed with the marine invertebrate Acartia tonsa (Hudson, 2003) according to ISO 14669 (1999) and ISO 5667-16 (1998) guidelines. Acartia tonsa was exposed to five test concentrations up to 100 mg/L prepared as WAFs (nominal concentration). The number of dead or immobile organisms was evaluated after 24 and 48 hours. Natural seawater, UV sterilized and filtered was used. The 48-hour LC50 value was 21 mg/L (nominal concentration).

The supporting study with C12 -14AS MEA (CAS 90583-16-7) was performed with Daphnia magna (Guhl 2004) according to OECD 202. Daphnids were exposed to seven test concentrations up to 90 mg/L (nominal concentration) in a static study. Inhibition of mobility was checked after 24 hours. The 24h LC50 was 14.7 mg a.i./L (21 mg/L for the tested product).

Moreover, in accordance to Regulation (EC) 1907/2006 Annex XI, 1.5, a read-across to other structurally related category members was conducted. Read-across data from the following substances were used: C12-14AS Na (CAS 85586-07-8) and C12-14AS TEA (CAS 90583-18-9). Toxicity of alkyl sulfates is dependent on the carbon chain length and the influence of the counter ion can be neglected.

The key, GLP study is available for C12-14AS Na (CAS 85586-07-8) according to EG Guideline 92/69/EWG (Scholz 1995a). In this freshwater study Daphnia magna was exposed in a static system to five concentrations up to 10 mg/L (nominal concentration corresponding to 9.5 mg/L of measured concentration) of C12-14AS Na of 29.8% purity (in water). The 48-hour EC50 value of 4.7 mg a.i./L (nominal concentration) could be determined. Composition of carbon chains of the tested category member C12-14AS Na (CAS 85586-07-8) is the same as of C12-14AS MEA (CAS 90583-16-7): both contain on average 65% of C12 and 35% of C14 chains. Due to structural and property similarity with the tested category member, the 48-hour EC50 value of 4.7 mg/L is considered as a reliable for C12-14AS MEA (CAS 90583-16-7).

Moreover, one reliable study investigating toxic effects of C12-14AS TEA (CAS 90583-18-9) to Daphnia magna is available. The GLP study was performed according to DIN 38412, part 1, equivalent to OECD 202 (Scholz 1995b). Inhibition of mobility of daphnids caused by the test substance was determined after 24 and 48 of static exposure to test substance up to 10 mg/L (nominal concentrations in agreement with measured concentration). The results showed that the 48-hour EC50 value was 7.1 mg a.i./L (nominal concentration).