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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Description of key information

The substance is considered as not bioaccumulative. It is proposed to use a BCF of 501 L/kg in the chemical safety assessment as this was the maximum predicted BCF.

Key value for chemical safety assessment

BCF (aquatic species):
501 L/kg ww

Additional information

The bioconcentration factor of the substance menthyl acetate was calculated with the BCFBAF program (as of September 2010, described in Meylan et al. 1999) using a fragment based QSAR model and with a QSAR model built on the relationship between the log Kow and BCF (Veith et al. 1979). The BCFs calculated with the models were 202 L/kg and 501 L/kg. Both values are below the cut-off value of 2000 L/kg triggering classification of substances as bioaccumulative. It is therefore concluded that the B criterion is not met for menthyl acetate and the substance is considered as not bioaccumulative. This conclusion is also supported by a valid study on the bioconcentration of DL-menthol in carp in accordance with OECD TG 305, which resulted in a maximum BCF value of 15 L/kg for this major metabolite of menthyl acetate.