Registration Dossier
Registration Dossier
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EC number: 211-519-9 | CAS number: 657-27-2
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20.05 - 03.06.2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study has been performed according to OECD guideline and according to GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Lysine hydrochloride
- EC Number:
- 211-519-9
- EC Name:
- Lysine hydrochloride
- Cas Number:
- 657-27-2
- Molecular formula:
- C6H14N2O2.ClH
- IUPAC Name:
- lysine hydrochloride
Constituent 1
Study design
- Analytical method:
- other: ion chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- < -3.3
- Temp.:
- 24 °C
- pH:
- 5.88 - 6.26
- Details on results:
- Before performing the partition coefficient test the log Pow value was calculated using the ALOGPS 2.1 program. This calculated value was -3.76. The experimental Pow should be calculated by dividing the determined n-octanol concentration by the determined water concentration. However, the determined n-octanol concentration was below the LOQ. Therefore, the determined log Pow value for the test substance was < -3.3.
Applicant's summary and conclusion
- Conclusions:
- The determined log Pow value for L-lysine HCl was < -3.3.
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