(R*,S*)-(±)-α-[1-(methylamino)ethyl]benzyl alcohol hydrochloride

Biodegradation in water: screening tests

Administrative data

Endpoint:

biodegradation in water: ready biodegradability

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study in compliance with GLP-criteria.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2002

Report date:

2002

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 301 A (Ready Biodegradability: DOC Die Away Test)

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

Ephedrine hydrochloride

EC Number:

200-074-6

EC Name:

Ephedrine hydrochloride

Cas Number:

50-98-6

IUPAC Name:

2-(methylamino)-1-phenylpropan-1-ol hydrochloride

Test material form:

solid: crystalline

Details on test material:

- Name of test substance:-Ephedrin-Hydrochlorid
- Chemical name: (1R, 2S)-2-Methylamino-l-phenyl-l-propanolhydrochlorid
- Aggregate state: solid, powder
- Colour: white
- Homogeneity: homogeneous
- Special conditions for storage: storage at room temperature

Study design

Oxygen conditions:

aerobic

Inoculum or test system:

activated sludge, non-adapted

Details on inoculum:

Activated sludge from laboratory wastewater plants treating municipal sewage.

Duration of test (contact time):

28 d

Initial test substance concentration

Initial test substance concentration 1

Initial conc.:

34 mg/L

Based on:

test mat.

Initial test substance concentration 2

Initial conc.:

20 mg/L

Based on:

DOC

Parameter followed for biodegradation estimation

Parameter followed for biodegradation estimation:

DOC removal

Details on study design:

TEST CONDITIONS:
- Test temperature: 22 ± 2 °C

PRELIMINARY INVESTIGATIONS:
- TOC (mg/g): 606
- DOC (mg/g): 611

Reference substance

Reference substance:

aniline

Results and discussion

Test performance:

- Degradation degree of the reference substance after 14 days (% DOC): 90-100
- Degradation degree in the inhibition control after 14 days (% DOC): 90-100
- Physico-chemical (abiotic) elimination of the test substance (% DOC): <10 at the end of the test
- Elimination of the test substance by adsorption (% DOC): <10 after 5 days

% Degradation

% Degradation 1

Parameter:

% degradation (DOC removal)

Value:

0 - 10

Sampling time:

5 d

% Degradation 2

Parameter:

% degradation (DOC removal)

Value:

40 - 50

Sampling time:

7 d

% Degradation 3

Parameter:

% degradation (DOC removal)

Value:

90 - 100

Sampling time:

14 d

% Degradation 4

Parameter:

% degradation (DOC removal)

Value:

90 - 100

Sampling time:

18 d

Details on results:

- Duration of the adaptation phase (days): 6
- Duration of the degradation phase (days): 11
- Degradation of the test substance at the end of the 10-day window (% DOC): 90-100
- Degradation degree of the test substance at the end of the test (% DOC): 90-100
- 10-day window criterion met: Yes

Any other information on results incl. tables

DOC decrease (%)

Day	RS	IH	PC	AC	TS1	TS2	TSmean
0	0	0	0	0	0	0	0
1	-4	0	7	3	0	0	0
3	2	3	4	4	1	-1	0
5	93	95	5	0	-3	-1	-2
7	89	95	13		93	4	49
10	88	94	4		95	92	94
14	92	96	3		96	95	96
17	95	98	4		98	98	98
18	94	97	6		98	98	98

RS: reference substance

IH: inhibition control

PC: abiotic control

AC: adsorption control

TS: test substance