Registration Dossier
Registration Dossier
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EC number: 203-755-6 | CAS number: 110-30-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Remarks:
- MHLW, Japan
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 0 mg/kg and 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- duration of test 14 days
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- none
- Clinical signs:
- other: none
- Gross pathology:
- none
- Other findings:
- none
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Guideline:
- other: unknown
- GLP compliance:
- not specified
- Species:
- rat
- Route of administration:
- inhalation: dust
- Duration of exposure:
- 6 h
- Sex:
- not specified
- Dose descriptor:
- LCLo
- Effect level:
- > 112 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Sex:
- not specified
- Dose descriptor:
- LCLo
- Effect level:
- > 6.3 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Sex:
- not specified
- Dose descriptor:
- LCLo
- Effect level:
- 58.2 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
Reference
In all experiments a mild and transient pulmonary inflammation response was noted
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 112 mg/m³ air
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Guideline:
- other: 16CFR 1500.40
- GLP compliance:
- not specified
- Species:
- rabbit
- No. of animals per sex per dose:
- 7
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 20 000 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 20 000 mg/kg bw
Additional information
Oral, rat
Justification for classification or non-classification
With an LD50 (oral, rat) of >2000 mg/kg, an LC50 (inhalation, rat, 6 hours) of > 122 mg/L and an LD50 (dermal, rabbit) of > 20000 mg/kg, this substance must not be classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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