Registration Dossier
Registration Dossier
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EC number: 203-755-6 | CAS number: 110-30-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- other: New Zealand
- Type of coverage:
- occlusive
- Amount / concentration applied:
- 500 mg in 1.2 ml polyethylene glycol 400 (approx. 40%)
- Duration of treatment / exposure:
- 24h
- Number of animals:
- 6
- Irritation parameter:
- primary dermal irritation index (PDII)
- Score:
- < 2
- Max. score:
- 8
- Reversibility:
- fully reversible
- Remarks on result:
- other: no further data available
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- other: New Zealand
- Vehicle:
- other: polyethylene glycol
- Amount / concentration applied:
- 100 mg substance in 0.4 ml polyethylene glycol (approx. 25%)
- Duration of treatment / exposure:
- eyes were rinsed after 24h
- Observation period (in vivo):
- 3 days
- Number of animals or in vitro replicates:
- 6
- Irritation parameter:
- overall irritation score
- Max. score:
- 110
- Reversibility:
- fully reversible
- Remarks on result:
- other: slightly irritating
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
In view of the experimental results on skin (OECD TG404) and eye (OECD TG405) the substance must not be classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
