Registration Dossier
Registration Dossier
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EC number: 206-532-1 | CAS number: 353-42-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented, non-guideline and non-GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyl ether-boron trifluoride
- EC Number:
- 206-532-1
- EC Name:
- Dimethyl ether-boron trifluoride
- Cas Number:
- 353-42-4
- Molecular formula:
- C2H6BF3O
- IUPAC Name:
- (dimethyloxo)trifluoro-λ⁵-borane
- Details on test material:
- - Name of test material (as cited in study report): Borfluorid-Methylaetherat
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: US rats
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- The test substance was given as 0.5% aqueous solution (25 mm3), 2% aqueous solution (200 mm3) and 4% solution (higher doses).
- Doses:
- 25, 200, 250, 320, 400, 500, 640, 800 mm3
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 resp. 14 days
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- ca. 496 mg/kg bw
- Remarks on result:
- other: original value: ca. 400 mm3/kg
- Mortality:
- 25, 200, 250 mm3: 0/10 after 7 days
320 mm3: 3/10 after 14 days
400 mm3: 6/10 after 7 days
500 mm3: 7/10 after 14 days
640 mm3: 9/10 after 14 days
800 mm3: 10/10 after 24 hours - Clinical signs:
- other: Apathy, ventral or lateral position, convulsions, dyspnoea.
- Gross pathology:
- Dilated stomach
Applicant's summary and conclusion
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