Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-532-1 | CAS number: 353-42-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented, non-guideline and non-GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyl ether-boron trifluoride
- EC Number:
- 206-532-1
- EC Name:
- Dimethyl ether-boron trifluoride
- Cas Number:
- 353-42-4
- Molecular formula:
- C2H6BF3O
- IUPAC Name:
- (dimethyloxo)trifluoro-λ⁵-borane
- Details on test material:
- - Name of test material (as cited in study report): Borfluorid-Methylaetherat
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: US rats
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- The test substance was given as 0.5% aqueous solution (25 mm3), 2% aqueous solution (200 mm3) and 4% solution (higher doses).
- Doses:
- 25, 200, 250, 320, 400, 500, 640, 800 mm3
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 resp. 14 days
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- approximate LD50
- Effect level:
- ca. 496 mg/kg bw
- Remarks on result:
- other: original value: ca. 400 mm3/kg
- Mortality:
- 25, 200, 250 mm3: 0/10 after 7 days
320 mm3: 3/10 after 14 days
400 mm3: 6/10 after 7 days
500 mm3: 7/10 after 14 days
640 mm3: 9/10 after 14 days
800 mm3: 10/10 after 24 hours - Clinical signs:
- other: Apathy, ventral or lateral position, convulsions, dyspnoea.
- Gross pathology:
- Dilated stomach
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
