Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 939-457-4 | CAS number: 1469983-50-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Surface tension
Administrative data
Link to relevant study record(s)
- Endpoint:
- surface tension
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 16 May 2012 to 06 December 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was conducted according to internationally recognised guidelines, and under GLP. No deviation affected the quality of the study. The study was performed on the commercial product (aqueous solution) as the test item is manufactured and used in a liquid form.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 115 (Surface Tension of Aqueous Solutions)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.5 (Surface Tension)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 2012-12-15
- Type of method:
- ring method
- Key result
- Surface tension:
- >= 37.3 - <= 37.7 mN/m
- Temp.:
- 20 °C
- Conc.:
- 1 g/L
- Remarks on result:
- other: mean surface tension of the test item at 1 g/L of active substance in water (corresponding to 1.33 g solid content/L)
- Conclusions:
- The mean surface tension of test item solution at 1g/L of active ingredient (corresponding to 1.33 g solid content/L): 37.5 ± 0.2 mN/m (corrected value). The test item was considered as surface-active in the experimental conditions used.
- Executive summary:
The surface tension of the test item (= substance EC 939-455-3 in aqueous commercial product) was investigated in a GLP-compliant study performed in accordance with OECD Guideline 115 (Surface Tension of Aqueous Solutions) and EU Method A.5 (Surface Tension). The mean surface tension of a test item solution at 1g/L of active ingredient (corresponding to 1.33 g solid content/L) was 37.5 ± 0.2 mN/m. The test item was considered as surface-active in the experimental conditions used.
The study was performed on a commercial product (aqueous solution) as the substance EC 939-455-3 is manufactured and used in a liquid form.
- Endpoint:
- surface tension
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- 1. HYPOTHESIS FOR THE ANALOGUE APPROACH
C8-C18 AAPHS and C12-18 AAPHS have the same functional groups, and general composition. The main variable resides in the alkyl chain distribution.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Source chemical = C8-18 cocamidopropyl hydroxysultaine (EC 939-455-3).
Target chemical = C12-18 cocamidopropyl hydroxysultaine (EC 939-457-4).
3. ANALOGUE APPROACH JUSTIFICATION
The alkyl C-chain distribution of the source chemical significantly overlaps with the one of the target chemical, the C12-alkyl derivative being the major constituent in both chemicals. The structural differences in side C-chains is not expected to lead to significant differences on phys-chem properties.
4. DATA MATRIX
See "Documentation and scientific justification of the read-across approach" in section 13.2. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Surface tension:
- >= 37.3 - <= 37.7 mN/m
- Conc.:
- 1.33 other: solid content
- Remarks on result:
- other: read-across from EC 939-455-3
- Conclusions:
- By analogy with the source substance EC 939-455-3, a surface tension of 37.5 ± 0.2 mN/m was reported for the target substance 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C12-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-457-4) at a concentration of 1.33 g solid content/L.
The source and target substances are both manufactured and used in a liquid form (aqueous solutions at a similar contentration range). The security physico-chemical parameters were therefore assessed from tests performed on aqueous solutions.
Referenceopen allclose all
Results of calibration with demineralized water :
Assay No. 1 |
|
Assay No. 2 |
|
Assay No. 3 |
|||
Temperature(°C) |
19.7 |
|
Temperature(°C) |
20.0 |
|
Temperature(°C) |
20.0 |
Time |
Surface tension (mN/m) |
|
Time |
Surface tension (mN/m) |
|
Time |
Surface tension( mN/m) |
T0 |
78.2 |
|
T0 |
78.2 |
|
T0 |
78.6 |
T0+ 2 min |
78.3 |
|
T0+ 2 min |
78.1 |
|
T0+ 2 min |
78.6 |
T0+ 4 min |
78.3 |
|
T0+ 3 min |
78.2 |
|
T0+ 3 min |
78.6 |
Results |
78.3 |
|
Results |
78.2 |
|
Results |
78.6 |
Mean surface tension of water : 78.4 ± 0.3 mN/m at 19.9°C
Calibration factor: 0.928
Results with test item at 1 g/l of active substance in deminseralized water:
Content of active substance in the test item : 36.2% w/w
Preparation of the solution : a quantity of 1.381 g of test item was weighed in a 500-mL volumetric flask and the volume was made up with demineralized water. The solution was manually shaking.
Assay No. 1 |
|
Assay No. 2 |
|
Assay No. 3 |
|||
Temperature(°C) |
20.0 |
|
Temperature(°C) |
20.1 |
|
Temperature(°C) |
20.1 |
Time |
Surface tension (mN/m) |
|
Time |
Surface tension (mN/m) |
|
Time |
Surface tension (mN/m) |
T0 |
42.4 |
|
T0 |
42.2 |
|
T0 |
42.2 |
T0+ 2 min |
42.5 |
|
T0+ 3 min |
42.2 |
|
T0+ 3 min |
42.3 |
T0+ 3 min |
42.5 |
|
T0+ 4 min |
42.3 |
|
T0+ 5 min |
42.3 |
The calculation of the surface tension is shown on the following table:
Assay |
Measurements (mN/m) |
Correction using Φb (mN/m) |
Correction according to Harkins & Jordan table (mN/m) |
State of equilibrium |
|||
1 |
42.5 |
39.3 |
37.5 |
2 |
42.3 |
||
3 |
42.3 |
||
Mean |
42.4 |
Description of key information
As the surface tension of the substance EC 939-457-4 have not been determined experimentally, a read-across approach was followed to fill in the endpoint. The surface tension of a structural analogue substance (= source substance EC 939-455-3) was investigated in a GLP-compliant study (Colombies, 2013) performed in accordance with OECD Guideline 115 (Surface Tension of Aqueous Solutions) and EU Method A.5 (Surface Tension). The mean surface tension of a solution at 1g/L of active ingredient (corresponding to 1.33 g solid content/L) was 37.5 ± 0.2 mN/m. The analogue substance was considered as surface-active in the experimental conditions used. By analogy, a surface tension of 37.5 ± 0.2 mN/m was reported for the target substance 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C12-18(even numbered) acyl) derivs., hydroxides, inner salts at a concentration of 1.33 g solid content/L (EC 939-457-4).
The alkyl C-chain distribution of the source substance EC 939-455-3 significantly overlaps with the one of the target substance EC 939-457-7, the C12-alkyl derivative being the major constituent in both chemicals. The structural differences in side C-chains is not expected to lead to significant differences on phys-chem properties.
Key value for chemical safety assessment
- Surface tension:
- 37.5
- in mN/m at 20°C and concentration in mg/L:
- 1 000
Additional information
The surface tension of the structural analogue substance (= source substance EC 939-455-3) was investigated in a GLP-compliant study (Colombies, 2013) performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and was selected as key study for the endpoint of the target substance EC 939-457-4.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.